| 王俊菊,李多杰,王晓敏.口腔鳞状细胞癌中Hh通路关键分子[J].中国肿瘤,2013,22(1):41-44. |
| 口腔鳞状细胞癌中Hh通路关键分子 |
| The Expression of Key Molecules (Shh/Ptch/Gli-1) in Hh Signaling Pathway in Oral Squamous Cell Carcinoma and Its Clinical Significance |
| 投稿时间：2012-03-19 |
| DOI：10.11735/j.issn.1004-0242.2013.01.A2012081 |
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| 中文关键词: 口腔鳞状细胞癌 Hh通路 Shh Ptch Gli-1 |
| 英文关键词:oral squamous cell carcinoma Hh signaling pathway Shh Ptch Gli-1 |
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| 中文摘要: |
| 摘 要：［目的］ 探讨Hh通路关键分子Shh、Ptch、Gli-1在口腔鳞状细胞癌中的表达及意义。［方法］采用免疫组织化学方法分别检测40例口腔鳞状细胞癌组织和30例口腔黏膜正常组织中Shh、Ptch、Gli-1的表达。［结果］ Shh、Ptch、Gli-1在30例正常口腔黏膜中均无表达，在口腔鳞状细胞癌中，Shh、Ptch、Gli-1阳性率分别为62.5%、60.0%和65.0%。Shh、Gli-1的阳性表达与肿瘤大小、淋巴结转移、临床分期相关（P<0.05），Ptch表达与淋巴结转移相关（P﹤0.05）。Spearman等级相关分析显示Shh、Ptch和Gli-1的表达间均存在正相关（rs=0.527、0.406、0.578，P<0.01）。［结论］ Shh、Ptch、Gli-1蛋白在口腔鳞状细胞癌组织中均过表达，三者可能通过配体依赖途径被激活并参与口腔鳞癌的发生发展、转移。 |
| 英文摘要: |
| Abstract: ［Purpose］ To investigate the expression of key molecules (Shh/Ptch/Gli-1) in Hh signaling pathway in oral squamous cell carcinoma (OSCC) and its clinical significance.［Methods］ The expression of Shh/Ptch/Gli-1 in 40 tissue samples with OSCC and 30 tissue samples with normal oral mucosa was detected by immunochemistry.［Results］ There was no expression of Shh/Ptch/Gli1 in normal oral mucosa tissue samples. The positive rate of Shh，Ptch and Gli-1 in oral squamous cell carcinoma was 62.5%，60.0% and 65.0% respectively. The expression of Shh and Gli-1 was related to the tumor size，lymph node metastasis and clinical stage（P<0.05），and the expression of Ptch was related to lymph node metastasis（P<0.05）. A positive correlation was found among the expression of Shh，Ptch and Gli-1(rs=0.527，0.406，0.578，P＜0.05). ［Conclusion］ Shh，Ptch and Gli-1 are over expression in OSCC. They may activated through ligand-dependent pathway and participated the carcinogenesis，progression and metastasis of OSCC. |
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