| This paper systematically explores the targeting mechanisms and application potential of nanoparticles in gastric cancer treatment. It focuses on analyzing the characteristics and applications of metallic nanoparticles, metal-organic frameworks, mesoporous silica nanoparticles, carbon-based nanomaterials, quantum dots, and green-synthesized inorganic nanoparticles. Research indicates that key properties of inorganic nanoparticles, such as particle size, shape, surface coating, and charge, significantly affect their in vivo behavior and therapeutic outcomes. Furthermore, this paper proposes design strategies for novel inorganic nanoparticles, including the application potential of microbe-mediated nanoparticle biosynthesis in tumor therapy, and emphasizes the importance of precise targeting strategies and targeting the tumor vasculature. Although inorganic nanoparticles still face challenges in clinical translation, such as complex manufacturing processes, biocompatibility, and standardization, their unique advantages make them promising tools for future precision treatment of gastric cancer. |
