| Colorectal cancer (CRC) is one of the common gastrointestinal malignancies, and its occurrence and development are closely related to genetic, environmental and dietary changes, of which environmental factors occupy an important position. With the continuous advancement of industrialization and urbanization, environmental endocrine disrupting chemicals (EDCs) have seriously affected public health safety. Studies have found that EDCs can enter the human body through drinking water, food and other routes, and can drive the occurrence and development of CRC in a variety of ways: ①destroying the intestinal mucosal barrier and inducing intestinal flora imbalance; ②affecting the expression and abnormal release of inflammatory factors; ③inducing oxidative stress; ④ activating PI3K/AKT, Wnt/β-catenin and other signaling pathways to promote cell proliferation-apoptosis imbalance and epithelial-mesenchymal transition (EMT) process. Studies have shown that EDCs are associated with the risk and progression of CRC. Therefore, this article reviews the origin and types of EDCs, their effects on CRC and possible regulatory mechanisms, and their potential value in CRC risk assessment and prognosis in order to provide a basis for studying potential environmental exposure risk factors for CRC and provide new ideas for the prevention and treatment of CRC. |
