| Autophagy is a process of cellular self-degradation that maintains homeostasis and has been shown to promote tumor progression in advanced stages. Pancreatic cancer cells and the surrounding stromal cells exhibit high levels of autophagy. Therefore, targeting autophagy has become a promising therapeutic approach for pancreatic cancer treatment. This review will focus on the research of targeting autophagy in pancreatic cancer treatment, introducing the roles and mechanisms of autophagy in pancreatic cancer cell proliferation, metastasis, immune microenvironment, and drug resistance. Additionally, we will summarize preclinical and clinical studies investigating autophagy-targeted therapies and combination treatments, aiming to provide new theoretical insights and therapeutic strategies for pancreatic cancer. |
