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| 2020年甘肃省肿瘤登记地区结直肠癌流行特征及2010-2020年变化趋势分析 |
| Analysis of the Epidemiological Characteristics of Colorectal Cancer in Gansu Province in 2020 and the Changing Trends from 2010 to 2020 |
| 投稿时间：2025-03-28 修订日期：2025-05-30 |
| DOI： |
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| 中文关键词: 结直肠癌 肿瘤登记 发病率 死亡率 趋势变化 甘肃 |
| 英文关键词:Colorectal cancer Tumor registration Incidence rate Mortality rate Trend change Gansu Province |
| 基金项目:甘肃省自然科学基金项目 |
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| 摘要点击次数: 51 |
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| 中文摘要: |
| [目的] 分析2020年甘肃省肿瘤登记地区结直肠癌发病与死亡现况及2010-2020年结直肠癌发病率及死亡率变化趋势。[方法] 整理甘肃省肿瘤登记地区上报的2020年结直肠癌数据，计算粗发病率、中标发病率、世标发病率、0-74岁累积发病率；粗死亡率、中标死亡率、世标死亡率、0-74岁累积死亡率等指标，利用Joinpoint模型计算平均年度变化百分比（Average annual percentage change,AAPC）与年度变化百分比（Annual percentage change,APC），分析2010-2020年间结直肠癌发病率与死亡率的变化趋势。[结果] 2020年甘肃省肿瘤登记地区结直肠癌粗发病率为23.18/10 万，中标发病率为14.41/10万，世标率为15.89/10万，累积率（0~74岁）为1.70%，在恶性肿瘤发病中占比为8.91%。结直肠癌死亡率为9.08/10万，中标率为5.43/10万，世标率为6.23/10万，累积率（0~74 岁）为0.60%，在恶性肿瘤死亡中占比为6.67%，结直肠癌发病率及死亡率低于国内多数地区。2010-2020年间全省中标发病率略有下降趋势（AAPC=-0.49,95%CI =-2.15~1.20），但趋势变化无统计学意义（P＞0.05）。而中标死亡率呈明显下降趋势（AAPC=-5.17，95%CI =-9.83~-0.26），趋势变化有统计学意义（P＜0.05）。分段分析结果显示，在2010-2017年间全省中标发病率略有上升（APC=2.25%，95%CI：-1.26~6.45），2017-2020年间略有下降（APC=-5.44%，95%CI：-12.33~2.00），但变化均无统计学差异（P＞0.05），在2010-2015年间全省中标死亡率呈上升趋势（APC=12.73%，95%CI：1.34~25.41），2015-2020年间呈下降趋势（APC=-13.99%，95%CI：-18.99~-8.68），均有统计学差异（P＜0.05）。在地区分布中，皋兰县结直肠癌发病率最高，张家川县死亡率最高，山丹县发病率与死亡率均最低。[结论] 2020年甘肃省肿瘤登记地区结直肠癌发病率及死亡率均略低于国内多数地区，2010-2020年间结直肠癌发病率呈现平稳态势，而死亡率呈下降趋势，持续做好早诊早治筛查工作与宣传，是实现发病率与死亡率双下降的重要举措。 |
| 英文摘要: |
| [Purpose] To analyze the current situation of the incidence and mortality of colorectal cancer in the cancer registration areas of Gansu Province in 2020 and the changing trends of the incidence and mortality of colorectal cancer from 2010 to 2020. [Methods] The data of colorectal cancer in 2020 reported by the cancer registration areas of Gansu Province were collated, and the crude incidence rate, age-standardized incidence rate by Chinese standard population (CSIR), age-standardized incidence rate by world standard population (WSIR), cumulative incidence rate (0-74 years old), crude mortality rate, age-standardized mortality rate by Chinese standard population (CSMR), age-standardized mortality rate by world standard population (WSMR), and cumulative mortality rate (0-74 years old) were calculated. The Joinpoint model is used to calculate the Average Annual percentage change (AAPC) and the Annual percentage change (APC). Analyze the changing trends of the incidence and mortality rates of colorectal cancer from 2010 to 2020. [Results] In 2020, the crude incidence rate of colorectal cancer in the cancer registration areas of Gansu Province was 23.18/105, the CSIR was 14.41/105, the WSIR was 15.89/105, and the cumulative incidence rate (0~74 years old) was 1.70%, accounting for 8.91% of the total incidence of malignant cancers. The mortality rate of colorectal cancer was 9.08/105, the CSMR was 5.43/105, the WSMR was 6.23/105, and the cumulative mortality rate (0-74 years old) was 0.60%, accounting for 6.67% of the total mortality of malignant cancers. The incidence and mortality rates of colorectal cancer were lower than those in most regions of China. From 2010 to 2020, the incidence of contracted contracted cases in the province showed a slight downward trend (AAPC=-0.49,95%CI =-2.15 ~ 1.20), but the trend change was not statistically significant (P > 0.05). However, the mortality of winning the bid throughout the province showed a significant downward trend (AAPC=-5.17, 95%CI =-9.83 ~ -0.26), and the trend change was statistically significant (P < 0.05). The segmented analysis revealed that the incidence rate of contracted contracted disease in the province slightly increased from 2010 to 2017 (APC=2.25%, 95%CI: -1.26 ~ 6.45). And from 2017 to 2020, it slightly decreased (APC = -5.44%, 95% CI: -12.33~2.00), with no statistical significance (P > 0.05). From 2010 to 2015, the CSMR showed an upward trend (APC = 12.73%, 95% CI: 1.34~25.41), and from 2015 to 2020, it showed a downward trend (APC = -13.99%, 95% CI: -18.99~ -8.68), with statistical significance (P < 0.05). In terms of regional distribution, Gaolan County had the highest incidence rate of colorectal cancer, and Zhangjiachuan County had the highest mortality rate, while Shandan County had the lowest incidence and mortality rates. [Conclusion] In 2020, the incidence and mortality rates of colorectal cancer in the tumor registration areas of Gansu Province were slightly lower than those in most regions of the country. From 2010 to 2020, the incidence rate of colorectal cancer showed a stable trend, while the mortality rate showed a downward trend. Continuously doing a good job in early diagnosis and early treatment screening and publicity is an important measure to achieve a double decline in the incidence and mortality rates. |
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