| 张 勇,王 斌,周幽心.人脑胶质瘤中APC、β-catenin及CyclinD1表达[J].中国肿瘤,2012,21(5):368-370. |
| 人脑胶质瘤中APC、β-catenin及CyclinD1表达 |
| The Expression of APC，β-catenin and CyclinD1 in Human Glioma |
| 投稿时间：2012-01-20 |
| DOI： |
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| 中文关键词: 胶质瘤；APC；β-catenin；CyclinD1 免疫组化 |
| 英文关键词:gliomas APC β-catenin CyclinD1 immunohistochemistry |
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| 中文摘要: |
| 摘 要：［目的］ 探讨APC、β-catenin、CyclinD1在人脑胶质瘤中的表达及意义。［方法］ 采用免疫组化Envision二步法检测APC、β-catenin、CyclinD1在48例胶质瘤和11例正常脑组织中的表达。［结果］ APC、β-catenin、CyclinD1的表达阳性率在正常脑组织与胶质瘤组均有显著性差异(100% vs 20.8%，0 vs 79.2%，0 vs 87.5%，P均<0.05)，胶质瘤中β-catenin与CyclinD1的表达呈正相关(r=0.427，P<0.05)，β-catenin与APC表达呈负相关(r=-0.621，P<0.05)。［结论］ 胶质瘤中APC低表达，β-catenin、CyclinD1高表达，可能在胶质瘤的发生发展中起一定作用。 |
| 英文摘要: |
| Abstract:［Purpose］ To investigate the expression of APC，β-catenin，CyclinD1 in human glioma.［Methods］ The expression of APC，β-catenin and CyclinD1 in tissue samples from 48 cases with glioma and 11 cases with normal brain tissue was detected by “Envision two steps”of immunohistochemistry. ［Results］ There was significant difference of the positive rate of APC，β-catenin and CyclinD1 between glioma tissue and normal brain tissue(100% vs 20.8%，0 vs 79.2%，0 vs 87.5%，P all <0.05). There was a positive correlation between β-catenin and CyclinD1 expression (r=0.427，P<0.05)，and negative correlation between β-catenin and APC expression (r=-0.621，P<0.05). ［Conclusion］ Low expression of APC， overexpression of β-catenin and CyclinD1 in glioma might correlate to carcinogenesis. |
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