| 蔡 滕,流小舟,樊根涛.巨噬细胞移动因子在骨肉瘤患者血清中的表达及临床意义[J].中国肿瘤,2012,21(7):552-555. |
| 巨噬细胞移动因子在骨肉瘤患者血清中的表达及临床意义 |
| Expression of Serum MIF in Patients with Osteosarcoma and its Clinical Significance |
| 投稿时间：2012-02-09 |
| DOI： |
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| 中文关键词: 骨肉瘤 巨噬细胞移动抑制因子 化疗 转移 |
| 英文关键词:osteosarcoma macrophage migration inhibitory factor chemotherapy metastasis |
| 基金项目:江苏省自然科学基金（BK 2010461） |
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| 中文摘要: |
| 摘 要：［目的］ 评价巨噬细胞移动因子（MIF）在骨肉瘤患者血清中的表达及临床意义。［方法］ 应用酶联免疫吸附分析（ELISA）方法，检测30名健康人（对照组）和32例骨肉瘤患者（病例组）初次入院、术后化疗前、术后化疗结束时血清MIF水平，分析MIF的表达与骨肉瘤临床病理特征的关系以及化疗对MIF水平的影响。 ［结果］ 病例组患者入院时血清MIF为（1.521±0.520）ng/ml，显著高于对照组的（1.149±0.284）ng/ml(t=3.452，P=0.001)。MIF的血清水平与骨肉瘤临床分期、肿瘤大小和转移存在相关性。患者化疗前血清中MIF水平显著高于化疗后（P<0.05）。［结论］ MIF在骨肉瘤患者血清中高表达，可能为骨肉瘤的重要预后因子及潜在的治疗靶点。 |
| 英文摘要: |
| Abstract:［Purpose］ To investigate the expression of serum macrophage migration inhibitory factor (MIF) in patients with osteosarcoma and its clinical significance. ［Methods］ The level of serum MIF of 30 healthy person (control group) and 32 cases with osteosarcoma (case group) at nitial hospitalization，before and after chemotherapy was detected by Enzyme-linked immunosorbent assay (ELISA). The relationship of MIF expression with clinicopathological features of osteosarcoma，and the effect of chemotherapy with the level of serum MIF were analyzed. ［Results］ The level of serum MIF of case group at nitial hospitalization［(1.521±0.520)ng/ml］ was significantly higher than that in control group ［(１.149±0284)ng/ml］(t=3.452，P=0.001). The level of serum MIF was related to osteosarcoma clinical stages，tumor size and metastasis. The level of serum MIF in patients pre-chemotherapy was significantly higher than that in patients post-chemotherapy. ［Conclusion］ MIF is high expression in patients with osteosarcoma，it may as a prognostic marker and a potential therapeutic target for osteosarcoma. |
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