| 郭文杰,许建华,卞秀华.调强放射治疗联合铂类化疗治疗局部晚期鼻咽癌预后分析[J].中国肿瘤,2012,21(12):940-943. |
| 调强放射治疗联合铂类化疗治疗局部晚期鼻咽癌预后分析 |
| An Analysis on Prognosis of Locoregionally Advanced Nasopharyngeal Carcinoma Treated with IMRT and Platinum-based Chemotherapy |
| 投稿时间：2012-09-11 |
| DOI： |
|
 |
|
| 中文关键词: 鼻咽癌 调强放疗 局部晚期 预后 |
| 英文关键词:nasopharyngeal carcinoma locoregionally advanced intensity?鄄modulated radiotherapy prognosis |
| 基金项目: |
|
| 摘要点击次数: 2258 |
| 全文下载次数: 874 |
| 中文摘要: |
| 摘 要：［目的］ 评价调强放射治疗联合铂类化疗治疗不同亚组局部晚期鼻咽癌的预后。［方法］ 将181例连续收治经病理学确诊的初治局部晚期鼻咽癌分为3组，以局部扩展为主要特征的T3~4N0~1M0 66例，以区域淋巴结转移为主要特征的T1～2N2～3M0 42例及混合型T3～4N2～3M0 73例，均采用调强放射治疗合并以铂类为基础的诱导化疗及同步化疗。中位随访24个月。［结果］ 局部扩展型、区域淋巴结转移型和混合型2年局部区域控制率分别为92.3%、100%及97.2%（P=0.32）；2年无远处转移生存率分别为91.1%，78.2%和76.3% (P=0.016)；2年无进展生存率分别为86.7%，78.2%和77.0%（P=0.095）。COX多因素分析示N分期是局部晚期鼻咽癌远处转移及疾病相关死亡的独立的危险因素（HR=2.99，95%CI：1.65~5.44；HR=3.20，95%CI：1.58~6.49）。［结论］ 在调强放疗联合铂类化疗的治疗背景下，局部及区域晚期鼻咽癌中N2～3亚组预相对较差，远处转移率及疾病相关死亡率上升。 |
| 英文摘要: |
| Abstract: ［Purpose］ To investigate the prognosis of locoregionally advanced nasopharyngeal carcinoma treated with intensity-modulated radiotherapy(IMRT) and platinum-based chemotherapy. ［Methods］ One hundred eighty-one patients with locally advanced nasopharyngeal carcinoma were retrospectively divided into three subgroups: locally advanced (T3~4N0~1M0) group(n=66)，regionally advanced (T1~2N2~3M0)group (n=42) and the mixed group(T3~4N2~3M0)(n=73). The patients were all treated with definitive intensity-modulated radiotherapy and platinum-based chemotherapy with median follow-up of 24 months.［Results］ The 2-year locoregional control(LRC) rate for locally advanced group，regionally advanced group，and the mixed type group was 92.3%，100% and 97.2% respectively(P=0.32)，the 2-year distant metastasis free survival(DMFS) rate was 91.1%，78.2% and 76.3% repectively(P=0.016)，the 2-year progress free survival(PFS) rate was 86.7%，78.2% and 77.0% respectively(P=0.095). Cox multivariates analysis showed that N stage was the only independent risk factor for distant metastasis and disease-specific death. ［Conclusions］ Based on IMRT and platinum-based chemotherapy，locoregionally advanced cases with N2~3 have a poor prognosis with a higher rates of distant metastasis and disease related death. |
|
在线阅读
查看全文 查看/发表评论 下载PDF阅读器 |