| 张 凯,孙 萍,郭兰伟.中国北方汉族女性HLA-DP/DQ基因多态性与宫颈癌易感性的关联研究[J].中国肿瘤,2013,22(6):442-447. |
| 中国北方汉族女性HLA-DP/DQ基因多态性与宫颈癌易感性的关联研究 |
| Association Study on Genetic Polymorphisms of HLA-DP/DQ and Susceptibility to Cervical Cancer in North Chinese Women |
| 投稿时间：2013-04-02 |
| DOI：10.11735/j.issn.1004-0242.2013.06.A201304122 |
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| 中文关键词: 宫颈癌 HLA-DP/DQ 基因多态性 易感性 |
| 英文关键词:cervical cancer HLA-DP/DQ genetic polymorphisms susceptibility |
| 基金项目:国家自然科学基金(No. 81172757)；北京市科技新星项目(No. XX2012067)；北京市自然科学基金(No. 7123225)；中国医学科学院肿瘤医院院所科研课题（2010YF45） |
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| 摘要点击次数: 2011 |
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| 中文摘要: |
| 摘 要：［目的］ 探讨中国北方女性HLA-DP和HLA-DQ的基因多态性与宫颈癌遗传易感性的关联。［方法］ 采用病例对照研究设计，收集北方汉族人群中831例新发宫颈癌患者和573例按年龄地区匹配的正常女性作为对照。应用TaqMan基因分型方法检测HLA-DP基因上的rs3077和rs9277535两个位点，以及HLA-DQ基因上的rs2856718和rs7453920位点。［结果］ 经Logistic回归分析显示，在调整年龄、吸烟、绝经状况、肿瘤家族史和活产胎次等因素后，携带HLA-DP rs3077 GA/AA基因型和HLA-DP rs9277535 GA/AA基因型者分别是HLA-DP GG基因宫颈癌发病风险的2.77倍（调整OR=2.77，95% CI：2.13~3.61）和1.66倍（调整OR=1.66，95% CI：1.25~2.20）。两位点的联合分析显示，与携带0个危险等位基因的个体相比，携带1~4个危险等位基因的个体患宫颈癌的风险增加（调整OR=2.38，95% CI：1.74~3.27），且随着携带危险等位基因个数的增加，宫颈癌的发病风险也逐步增加，呈现明显的剂量反应关系（P趋势=1.19×10-11）。但HLA-DQ基因上的rs2856718和rs7453920与宫颈癌的发病风险无显著性关联（P>0.05）。［结论］ HLA-DP基因上的rs3077和rs9277535可能是中国北方女性宫颈癌的易感性位点，但该结论还需要大样本前瞻性研究的验证及功能学研究的解释。 |
| 英文摘要: |
| Abstract: ［Purpose］ To investigate the relationship of HLA-DP and HLA-DQ genetic polymorphisms with susceptibility to cervical cancer in North Chinese women.［Methods］ A case-control study was conducted in 831 cases with cervical cancer and 573 health control matched by age and area. HLA-DP(rs3077 and rs9277535) and HLA-DQ(rs2856718 and rs7453920) was detected by TaqMan allelic discrimination assay.［Results］ Logistic regression analysis showed that the cervical cancer risk in person with HLA-DP rs3077 GA/AA was 2.77 times of that in person with HLA-DP rs3077 GG(95%CI: 2.13~3.61)，and HLA-DP rs9277535 GA/AA was 1.66 times(95%CI: 1.25~2.20) after ajusted by age，somking，menopausal status，family history of cancer and parity.When combining the effects of HLA-DP rs3077 and rs9277535，subjects carrying “≥1” variant alleles increased risk of cervical cancer(OR=2.38，95%CI:1.74~3.27)，compared with those carrying “0” variant allele. And cervical cancer risk significantly increased with the increasing number of variant alleles of the two SNPs in a dose-dependent manner(Pfor trend=1.19×10-11). However，significant association between HLA-DQ rs2856718 and rs7453920 with cervical risk was not observed(P>0.05).［Conclusions］ HLA-DP rs3077 and rs9277535 may be susceptibility markers for cervical cancer in North Chinese females. Further validation studies with large sample size，biological function analysis are needed. |
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