| 龚虹云,宋启斌,胡伟国.根治性放疗与根治性手术治疗肌层浸润性膀胱癌的Meta分析[J].中国肿瘤,2013,22(8):671-675. |
| 根治性放疗与根治性手术治疗肌层浸润性膀胱癌的Meta分析 |
| A Meta-analysis of Radical Radiotherapy or Radical Cystectomy for Patients with Bladder Cancer Muscle Invaded |
| 投稿时间：2013-04-01 |
| DOI：10.11735/j.issn.1004-0242.2013.08.A013 |
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| 中文关键词: 膀胱癌 根治性手术 根治性放疗 生存率 Meta分析 |
| 英文关键词:bladder cancer radical cystectomy radical radiotherapy survival Meta-analysis |
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| 摘要点击次数: 2358 |
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| 中文摘要: |
| 摘 要：［目的］ 系统评价根治性放疗与根治性手术治疗膀胱癌临床效果。［方法］ 应用ENDNOTE软件全面检索Pubmed（1973~2013年）数据库，对符合纳入标准的临床对照试验，采用RevMan 4.3软件进行Meta分析。对于无对照临床研究资料，采用同质合并分析。［结果］ 共纳入6个临床对照试验，共1 264例患者，Meta分析结果显示，根治性放疗与根治性手术切除治疗膀胱癌患者的5年生存率无统计学差异 (P=0.36)，合并比值比 (OR) 为1.10 (95%CI：0.86~1.40)。18篇无对照临床研究共纳入根治性放疗治疗膀胱癌患者1 749例，多数文献采用全膀胱放疗40~60Gy，联合以顺铂为基础的化疗方案，完全反应率达到65%以上，平均5年总生存率在50%以上，最低为37%，最高可达82%。［结论］ 根治性放疗不会降低膀胱癌患者生存率，且能维持正常膀胱功能，提高了患者生存质量。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the response of radical cystectomy or radical radiotherapy for patients with bladder cancer muscle invaded. ［Methods］ The trails(randomized controlled trails and uncontrolled clinical trials) in Pubmed（1973～2013）were searched by ENDNOTE software. Meta-analysis was performed on the results of homogenous studies by RevMan 4.3.［Results］ Six controlled clinical trials(1264 patients) were enrolled. The Meta-analysis results showed no statistical difference of 5-year survival between radical radiotherapy treatment group and radical surgery group (OR=1.10，95%CI: 0.86～1.40，P=0.36). Eighteen clinical uncontrolled trials (1749 patients underwent by radical radiotherapy) were enrolled，most of the patients underwent radical radiotherapy(40～60Gy) and combined with cisplatin based chemotherapy. The complete response rate achieved 65%，the average 5-year survival was more than 50%( 37%～82%). ［Conclusions］ Radical radiotherapy will not reduce the survival rate in patients with bladder cancer muscle invaded. And it can maintain the normal bladder function and improve quality of life. |
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