| 朱 奇,康静波,聂 青.康莱特联合体部伽玛刀治疗局部晚期胰腺癌28例[J].中国肿瘤,2013,22(11):931-934. |
| 康莱特联合体部伽玛刀治疗局部晚期胰腺癌28例 |
| Kanglaite Injection Combined with γ-ray Stereotactic Body Radiation Therapy for 28 Cases with Locally Advanced Pancreatic Cancer |
| 投稿时间：2013-03-11 |
| DOI：10.11735/j.issn.1004-0242.2013.11.A020 |
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| 中文关键词: 康莱特注射液 体部伽玛刀 胰腺癌 |
| 英文关键词:Kanglaite injection γ-ray stereotactic body radiation therapy pancreatic cancer |
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| 摘要点击次数: 2004 |
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| 中文摘要: |
| 摘 要：［目的］ 观察康莱特注射液（Kanglaite injection，KLT）联合体部伽玛刀对局部晚期胰腺癌的治疗效果。［方法］ 55例局部晚期胰腺癌患者随机分为两组，研究组28例：采用体部伽玛刀治疗，PTV覆盖95％以上临床靶体积（clinical target volume，CTV），等剂量曲线为50％～60％。肿瘤单次周边剂量3.0~4.5Gy，治疗 9～12次，同时给予康莱特注射液200ml/d，21d为1个疗程，共2个疗程。对照组：单纯行体部伽玛刀治疗。3个月后评价疗效，通过KPS评分、体重及疼痛变化，观察生存质量改善情况。［结果］ 两组完全缓解率分别为28.6%（8/28）和18.5%（5/27）；有效率分别为82.1%（23/28）和74.1%（20/27）。研究组Ⅲ级以上胃肠道反应发生率为3.5%（1/28），对照组为29.6%（8/27）；研究组未发生Ⅲ级以上骨髓抑制（0/28），对照组为18.5%（5/27）；研究组未发生Ⅲ级以上放射性肠炎（0/28），对照组为14.8%（4/27）；研究组治疗前后KPS评分、体重增高及疼痛症状缓解明显高于对照组（P＜0.05)。［结论］ 体部伽玛刀治疗局部晚期胰腺癌安全有效，可提高局控率和有效率。康莱特配合体部伽玛刀治疗胰腺癌可以减轻治疗过程中胃肠道反应，减少Ⅲ级以上骨髓抑制和Ⅲ级以上放射性肠炎的发生，减轻疼痛症状，改善患者的生存质量。 |
| 英文摘要: |
| Abstract：［Purpose］ To evaluate the clinical efficacy and toxicity of Kanglaite injection combined with γ-ray body stereotactic radiation in the treatment of locally advanced pancreatic cancer. ［Methods］ Fifty-five patients with locally advanced pancreatic cancer were randomized into two groups.The combination group received γ-ray stereotactic body radiation with isodose curve of 50%~60%，tumor encircling dose of 3.0~4.5 Gy per fraction for 9~12 fractions.Combined with Kanglaite injection 200ml/d for consecutive 21 days for two courses. Control group underwent γ-ray stereotactic body radiation alone.Toxicities and response were evaluated according to the criteria of WHO and RTOG.［Results］ The CR in combination group and control group was 28.6%（8/28） and 18.5%（5/27）respectively(P＞0.05).Response rate of combination group was 82.1%（23/28）and 74.1%（20/27）in control group(P＞0.05).The rate of grade 3~4 gastrointestinal tract side reaction，grade 3~4 myelosuppression and grade 3~4 radiation enterocolitis in combination group and control group were 3.5%（1/28），0%（0/28），0%（0/28）and 29.6%（8/27），18.5%（5/27），14.8%（4/27），respectively(P＜0.05).KPS and body weight score significantly increased and pain relieved in combination group after treatment(P＜0.05).［Conclusion］ Body gamma system treatment for pancreatic carcinoma can improve local control rate and effect for inoperable patients with local advanced pancreatic carcinoma. Kanglaite injection combined with γ-ray stereotactic body radiation Therapy can relieve severe toxicity in the treatment of locally advanced pancreatic cancer and improve quality of life. |
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