| 刘 炬,徐志坚,张 凯.体检人员常见肿瘤标志物异常的临床意义[J].中国肿瘤,2013,22(12):1029-1032. |
| 体检人员常见肿瘤标志物异常的临床意义 |
| Clinical Significance of Tumor Marker Elevation in Screened Person |
| 投稿时间：2013-04-07 |
| DOI：10.11735/j.issn.1004-0242.2013.12.A016 |
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| 中文关键词: 恶性肿瘤 早期诊断 肿瘤标志物 体检 |
| 英文关键词:cancer early detection tumor marker elevation physical examination |
| 基金项目:北京希望马拉松专项基金 （N2009YF51） |
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| 摘要点击次数: 1890 |
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| 中文摘要: |
| 摘 要：［目的］ 探讨体检发现肿瘤标志物异常对诊断肿瘤的临床意义。［方法］ 129例常规体检发现的肿瘤标志物（CEA、CA199、CA724、CA125、CA242、SCC、NSE、CYFRA211）升高人员，对其进行颈胸部、腹盆部CT、内窥镜检查，女性进行妇科检查，未明确诊断者进行长期随访（大于6个月）。 ［结果］ 经过随访，共发现肿瘤患者22例，其中发现肿瘤标志物升高6个月内诊断为恶性肿瘤15例(68.2%)，6个月至1年诊断3例(13.9%)，1年至2年诊断2例(9.1%)，2年至3年诊断2例(9.1%)。COX分析显示肿瘤标志物升高的程度(RR=1.154，95%CI：1.078~1.237，P<0.001)、肿瘤标志物逐渐升高(RR=3.863，95%CI：1.504~9.919，P<0.005)和有相关临床症状(RR=3.935，95%CI：1.178~13.14，P<0.05)是体检肿瘤标志物升高人员患肿瘤的危险因素。［结论］ 对于体检发现的肿瘤标志物升高人员，应进行全面的临床检查并进行长期随访。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the clinical significance of tumor marker elevation during physical examination in diagnosis for tumor.［Methods］ One hundred and twenty-nine screened person with elevated tumor marker(CEA，CA199，CA724，CA125，CA242，SCC，NSE，CYFRA211) were collected. Cervical，thorax，abdominal and pelvic CT，gastric endoscopy and colonoscopy were carried out for them. TCT and HPV were also performed for female. Uncerating persons were followed up for a long term(more than 6 months).［Results］ After follow up，there were 22 cancer patients was found. Among them，15 cases (68.2%) were diagnosed within 6 months from the elevation of tumor markers，3 cases (13.9%) within one year，2 cases (9.1%) within two years，and 2 cases(9.1%) within three years. COX analysis showed that degree elevated tumor markers(RR=1.154，95%CI：1.078~1.237，P<0.001)，tumor markers increased gradually (RR=3.863，95%CI：1.504~9.919，P<0.005) and relevant symptoms (RR=3.935，95%CI：1.178~13.14，P<0.05) were the cancer risk factors of screened person.［Conclusions］ Systemic clinical examination and long-term follow up should be carried out for person with elevated tumor marker. |
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