| 陈铁晖,郑奎城,林曙光.福建省胃癌中低发地区居民血清胃蛋白酶原亚群、胃泌素-17和幽门螺杆菌感染水平分布特征及影响因素[J].中国肿瘤,2014,23(3):209-213. |
| 福建省胃癌中低发地区居民血清胃蛋白酶原亚群、胃泌素-17和幽门螺杆菌感染水平分布特征及影响因素 |
| Distributing Characteristics and Their Influencing Factors of Serum Pepsinogens，Gastrin-17，Helicobacter Pylori Infection in Residents in Medium-Low Incidence with Gastric Cancer in Fujian |
| 投稿时间：2013-07-02 |
| DOI：10.11735/j.issn.1004-0242.2014.03.A008 |
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| 中文关键词: 胃癌 胃蛋白酶原Ⅰ 胃蛋白酶原Ⅱ 胃泌素-17 幽门螺杆菌 |
| 英文关键词:gastric cancer pepsinogenⅠ pepsinogen Ⅱ gastrin-17 helicobacter pylori |
| 基金项目:国家卫生计生委共建科学基金—福建省卫生教育联合攻关计划项目（WKJ-FJ-18） |
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| 中文摘要: |
| 摘 要：［目的］ 了解福建省胃癌中低发地区居民血清PGⅠ、PGⅡ、G-17和Hp感染水平分布特征，探讨用上述血清学标志物筛查高危人群的可能性。［方法］ 在同安区和福安市随机抽取调查对象进行问卷调查，检测血清PGⅠ、PGⅡ、G-17和Hp感染水平。［结果］ PGⅠ水平呈明显的性别、年龄、地区分布差异，PGⅡ、PGⅠ/PGⅡ水平呈明显的地区分布差异。不同Hp感染状态下PGⅠ、PGⅡ、PGⅠ/PGⅡ、G-17水平呈明显差异（P均<0.05）。Logistic回归分析未发现影响PGⅠ、PGⅠ/PGⅡ水平异常的因素，但G-17水平异常的危险因素为Hp感染（OR=2.656）和中年年龄(OR=2.114)。［结论］ PGⅠ、PGⅡ、G-17筛查胃癌高危人群具有较广阔的前景。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the distributing characteristics of serum PGⅠ，PGⅡ，G-17 and Hp infection in residents in areas with medium-low incidence of gastric cancer in Fujian，and the possibility of using serum markers screening high-risk groups.［Methods］ The person being investigated randomly from Tongan district and Fuan city received the interview questionnaires and were detected serum PGⅠ，PGⅡ，G-17，Hp detection. ［Results］ PGⅠ level showed significant differences in gender，age，region distribution. PGⅡ，PGⅠ/ PG Ⅱ level also showed significant difference in region distribution. PGⅠ，PGⅡ，PGⅠ/PGⅡ，G-17 level were significantly different between positive Hp infection and negative Hp infection(all P<0.05). Logistic regression analysis showed no factor caused abnormal levels of PGⅠ，PGⅠ/PGⅡ，but Hp infection(OR=2.656) and middle aged (OR=2.114) were high risks for G-17 abnormal levels. ［Conclusion］ PG Ⅰ，PG Ⅱ，G-17 have a broad prospect of screening for high-risk population with gastric cancer. |
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