| 叶盛威,王明伟,陈琼荣.USP2和CyclinD1蛋白在胃癌中的表达及其临床意义[J].中国肿瘤,2014,23(3):257-260. |
| USP2和CyclinD1蛋白在胃癌中的表达及其临床意义 |
| Expression of USP2 and CyclinD1 in Gastric Carcinoma and Its Clinicopathologic Significance |
| 投稿时间：2013-10-07 |
| DOI：10.11735/j.issn.1004-0242.2014.03.A018 |
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| 中文关键词: 胃癌 USP2 Cyclin D1 远处转移 TNM分期 |
| 英文关键词:gastric carcinoma USP2 CyclinD1 distant metastasis TNM stage |
| 基金项目:湖北省自然科学基金资助项目（2012FFB01703）； |
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| 中文摘要: |
| 摘 要：［目的］ 分析胃癌中USP2蛋白和CyclinD1蛋白的表达及其临床意义。［方法 ］ 应用免疫组化方法检测胃癌组织和相应癌旁组织中USP2蛋白和Cyclin D1蛋白的表达情况，并与胃癌临床病理因素进行相关性分析。［结果］ 胃癌组织中USP2蛋白阳性表达率为63.3%（69/109），而癌旁组织中USP2阳性表达率为33.7%(34/101)，两组比较有统计学差异（χ2=18.428，P<0.001）。胃癌组织中CyclinD1蛋白的阳性表达率为41.1%（49/111）。 胃癌组织中USP2表达与CyclinD1表达高度相关（P=0.005）；胃癌组织中Cyclin D1表达与远处转移和TNM分期呈正相关。［结论］ 胃癌组织中USP2异常表达可能通过其底物蛋白CyclinD1促进胃癌发展并影响患者的预后。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the USP2 and CyclinD1 expression in gastric carcinoma and their clinicopathologic significance. ［Methods］ The expressions of USP2，CyclinD1 in gastric carcinoma tissue and paracancerous tissue were examined by immunohistochemistry. The relationship of USP2，CyclinD1 proteins and clinicopathologic significance in gastric carcinoma was analyzed. ［Results］ The positive rate of USP2 protein expression in gastric carcinoma and paracancerous tissue was 63.3%（69/109） and 33.7%(33.7/101)，respectively with significant difference（χ2=18.428，P<0.001）.The positive expression rate of CyclinD1 protein in gastric carcinoma was 41.1%（49/111）. There was significant positive correlation between expression of USP2 and CyclinD1 in cancerous tissues（P=0.005）. There was also positive correlation between expression of CyclinD1 in cancer tissues and distant metastasis and TNM stage.［Conclusion］ Abnormal USP2 expression in gastric carcinoma may influence prognosis through CyclinD1 as a substrate. |
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