| 王 静,许可葵,史百高.4374例宫颈癌患者预后及其影响因素分析[J].中国肿瘤,2014,23(4):281-288. |
| 4374例宫颈癌患者预后及其影响因素分析 |
| An Analysis of the Prognostic Factors in 4374 Cases with Cervical Cancer |
| 投稿时间：2013-05-31 |
| DOI：10.11735/j.issn.1004-0242.2014.04.A003 |
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| 中文关键词: 宫颈癌 预后 生存分析 |
| 英文关键词:cervical cancer prognosis survival analysis |
| 基金项目: |
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| 中文摘要: |
| 摘 要： ［目的］ 分析宫颈癌患者的生存情况及影响预后的相关因素。［方法］ 对1992年1月至2005年12月湖南省肿瘤医院收治的4374例宫颈癌患者进行回顾和随访，采用Kaplan-Meier法和Cox比例风险模型分析影响预后的相关因素。［结果］ 全组患者因宫颈癌死亡1603例。1、3、5年生存率分别为95%、85%、77%，中位生存时间175.3个月。单因素分析显示年龄、绝经情况、经产道分娩次数、病理类型、分化程度、FIGO分期、治疗方法均与预后相关。亚组分析显示，Ⅰb1期患者单纯手术生存率较高（5年生存率94%），Ⅰb2期患者基于手术的放疗（5年生存率84%）和联合化放疗生存率（5年生存率80%）较高，Ⅱ期患者手术+放疗（5年生存率75%）及根治性放疗（5年生存率75%）的生存率较高，Ⅲ期患者根治性放疗（5年生存率60%）的生存率较高。Cox回归分析显示，FIGO分期、病理类型和治疗方法是影响预后的独立因素。［结论］ 年龄、绝经情况、经产道分娩次数、临床分期、病理类型和治疗方法可能是宫颈癌患者预后的影响因素，但本研究因采用非随机设计，无法比较各治疗方法的优劣。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the survival of patients with cervical cancer and analyze the prognostic factors.［Methods］ Patients with cervical cancer (4374 cases) treated in Hunan Provincial Tumor Hospital from January 1992 to December 2005 were reviewed and followed up. Kaplan-Meier method and Cox proportional hazard model were used for statistic analysis. ［Results］There were 1603 patients died of cervical cancer. The 1，3，and 5-year survival were 95%，85% and 77% respectively，the median survival was 175.3 months. Univariate analysis showed that survival was related to age，menopause status，times of delivery through the birth cancel，pathological types，differentiation，FIGO staging and treatment method.Patients in stage Ⅰb1 treated with surgery alone had higher survival (5-years survival was 94%)；Patients in stage Ⅰb2 treated with surgery+radiotherapy or cheomtherapy+radiotherapy had higher survival(5-years survival was 84% and 80%)；Patients in stageⅡtreated with surgery+radiotherapy or palliative radiotherapy had higher survival (5-years survival all was 75%)；Patients in stage Ⅲ treated with radiotherapy had higher survival(5-years survival was 60%). ［Conclusion］ Age，menopause status，FIGO staging，pathological types and treatment method may be prognostic factors of patients with cervical cancer. Since the design of the study was non-randomized，the therapeutic superiority could not be well compared. |
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