| 徐裕金,马红莲,白 雪.CBCT图像引导下SBRT治疗肺部原发灶或转移灶的初步研究[J].中国肿瘤,2014,23(4):338-341. |
| CBCT图像引导下SBRT治疗肺部原发灶或转移灶的初步研究 |
| Stereotactic Body Radiation Therapy Guided by Cone Beam Computed Tomography for Primary or Metastatic Lung Malignancy |
| 投稿时间：2013-11-12 |
| DOI：10.11735/j.issn.1004-0242.2014.04.A014 |
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| 中文关键词: 非小细胞肺癌 立体定向放疗 疗效 |
| 英文关键词:non-small cell lung cancer stereotactic body radiation therapy efficacy |
| 基金项目: |
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| 中文摘要: |
| 摘 要:［目的］ 评价CBCT图像引导技术下SBRT治疗原发性肺癌或肺转移瘤的安全性和初步疗效。［方法］ 2012年8月至2013年10月共9例患者在浙江省肿瘤医院接受CBCT图像引导下SBRT胸部放疗，中位年龄68岁。每次照射前行KV级CBCT扫描并在线配准。每次照射剂量5.0~12.5Gy，每日1次，中位照射次数8次（4~10次）；BED 76.8~112.5Gy（中位96Gy）。［结果］ 9例患者均安全完成放疗，总有效率为77.8%。其中CR 1例(11.1%)，PR 6例(66.7%)，SD 2例(22.2%)，无PD患者，未出现3度以上放射性毒副反应。中位随访8.8个月（1.3~14.6个月），1年局部控制率及总生存率分别为88.9%和100%。［结论］ CBCT图像引导下SBRT治疗早期肺癌或肺转移瘤近期疗效明确，毒副反应低，远期疗效有待进一步随访。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the clinical efficacy and toxicity of image-guided stereotactic body radiation therapy (SBRT) with daily online cone beam computed tomography(CBCT) for primary or metastatic lung malignancy.［Methods］ Nine patients with primary or metastatic lung cancer who received CBCT-guided SBRT from Aug 2012 to Oct 2013 in Zhejiang Cancer Hospital were retrospectively analyzed.The median age was 68 years. Daily online cone beam computed tomography was used before each treatment. SBRT was prescribed that fractional dose was 5.0~12.5Gy daily with median of eight fractions(4~10). The biological equivalent dose(BED) ranged from 76.8 to 112.5Gy（median 96Gy）. ［Results］ Nine patients completed the planned radiation. The overall response rate was 77.8%(7/9). One(11.1%) patient achieved CR；6(66.7%)，PR；2(22.2%)，SD；none PD. No grade 3 or up toxicities was found. The median follow-up was 8.8 months(1.3~14.6 months)，the 1-year local control rate and overall survival were 88.9% and 100%，respectively.［Conclusion］ SBRT with daily online CBCT for primary or metastatic lung cancer achieves excellent short-term response with low toxicity，long-term response needs further follow-up. |
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