| 王湘连,张立波,姚 晔.影像引导乳腺癌调强放疗的临床研究[J].中国肿瘤,2014,23(5):426-429. |
| 影像引导乳腺癌调强放疗的临床研究 |
| Clinical Research of Image Guided Intensity Modulated Radiotherapy for Breast Cancer |
| 投稿时间：2013-12-10 |
| DOI：10.11735/j.issn.1004-0242.2014.05.A017 |
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| 摘要点击次数: 2003 |
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| 中文摘要: |
| 摘 要：［目的］ 分析影像引导在降低乳腺癌放疗摆位误差中的影响。［方法］ 2012年1月至2012年7月收治乳腺癌28例采用调强放疗，肿瘤剂量为50Gy，保乳患者瘤床加量10Gy。采用影像引导放疗，放疗前行锥形束CT（CBCT）扫描，校正后记录摆位误差，治疗床纠正后再行CBCT扫描，记录摆位误差，比较两次摆位误差。［结果］ 患者治疗前左右方向（X轴）、头脚方向（Y轴）和腹背方向（Z轴）的摆位误差分别为0.24±0.21cm，0.44±0.32cm，0.20±0.21cm，治疗床纠正后的摆位误差分别为0.06±0.08cm，0.08±0.08cm，0.06±0.09cm，两组误差值比较均有统计学意义（P值均<0.05）。随访6～12个月，28例患者无一例出现放射性心肺损伤。急性皮肤反应1级10例，无2级及2级以上反应。［结论］ CBCT引导乳腺癌调强放疗降低了摆位误差，提高了放疗精度，正常组织反应可耐受。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the effects of cone-beam CT in reducing setup errors of radiotherapy for breast cancer. ［Methods］ Twenty-eight patients with breast cancer from Jan 2012 to Jul 2012 received intensity modulated radiotherapy with tumor dose 50Gy，10Gy boost dose was given to breast conserving patients. Before treatment and after correcting the treatment couch，patients were received cone-beam CT scan respectively，the setup error was compared. ［Results］ The setup errors before treatment on X，Y，Z axis were 0.24±0.21cm，0.44±0.32cm，0.20±0.21cm； and 0.06±0.08cm，0.08±0.08cm，0.06±0.09cm after post-correction respectively. Compare before treatment and post-correction group，setup errors were significant different(P<0.05). Followed up 6~12 months，no patient had radiation heart damage and pneumonitis. Acute radiation skin reaction grade 1 was observed in 10 patients，grade 2 and more than grade 2 were not found. ［Conclusions］ Cone-beam CT guided intensity modulated radiotherapy reduces the setup errors of breast cancer and elevate radiation the accuracy. The normal tissue reaction is tolerable. |
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