| 翁 翔,顾 超,翟丽娜.硼替佐米在多发性骨髓瘤治疗中的应用[J].中国肿瘤,2014,23(8):674-679. |
| 硼替佐米在多发性骨髓瘤治疗中的应用 |
| Application of Bortezomib to the Treatment of Multiple Myeloma |
| 投稿时间：2014-01-22 |
| DOI：10.11735/j.issn.1004-0242.2014.08.A010 |
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| 中文关键词: 硼替佐米 多发性骨髓瘤 治疗 |
| 英文关键词:bortezomib multiple myeloma treatment |
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| 中文摘要: |
| 摘 要：多发性骨髓瘤（MM）是一种浆细胞恶性肿瘤，其特征是骨髓中浆细胞克隆性增殖，分泌单克隆免疫球蛋白或其片段（M蛋白），同时伴有广泛的溶骨病变及贫血、感染、肾功能损害等临床表现。硼替佐米是一种新型的蛋白酶体抑制剂，通过全新机制达到抗骨髓瘤作用。临床上硼替佐米单药及同其他常规化疗药物组成的联合方案对初治、复发/难治的MM患者均取得了良好的疗效。全文就硼替佐米治疗多发性骨髓瘤的临床进展作一综述。 |
| 英文摘要: |
| Abstract：Multiple myeloma is a plasma cell malignancy，characterized by clonal expansion of plasma cells in bone marrow，and monoclonal immunoglobulin or the fragment (M protein) produced by plasma cells，together with a wide range of dissolved bone lesions and clinical manifestations such as anemia，infection，impaired renal function. Bortezomib is a new type of proteasome inhibitors，which can fight against multiple myeloma through new mechanism. Bortezomib，as a single agent or being combined with other conventional chemotherapy agent，has positive therapeutic effect on patients with newly diagnosed or relapsed/refractory multiple myeloma. In this article，the clinical application of bortezomib to the treatment of multiple myeloma is reviewed. |
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