| 谢克俭,陈映鹤,谢 辉.前列腺癌患者血清腺激肽释放酶2检测的临床意义[J].中国肿瘤,2014,23(8):695-698. |
| 前列腺癌患者血清腺激肽释放酶2检测的临床意义 |
| Detection of Serum Human Kallikrein 2 in Patients with Prostatic Cancer and Its Clinical Significance |
| 投稿时间：2013-10-22 |
| DOI：10.11735/j.issn.1004-0242.2014.08.A014 |
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| 中文关键词: 腺激肽释放酶2 前列腺肿瘤 诊断 |
| 英文关键词:human kallikrein 2 prostatic neoplasms diagonis |
| 基金项目:浙江省教育厅科研基金资助项目（Y201120586） |
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| 中文摘要: |
| 摘 要：［目的］ 探讨前列腺癌（PCa）患者血清腺激肽释放酶2（human kallikrein 2，hK2）检测的临床意义。［方法］ 采用酶联免疫吸附试验（ELISA）和放射免疫分析法（RIA）分别检测30例PCa、30例前列腺增生（BPH）患者和30名健康人血清hK2和前列腺特异性抗原（PSA）的水平。并随访12例行根治性前列腺全切术后PCa患者hK2水平。［结果］ PCa组hK2水平为78.8±25.2ng/L，明显高于BPH组（25.4±6.28ng/L）和健康组（24.1±4.16ng/L），差异有统计学意义（P<0.001）；BPH组与健康组比较差异无统计学意义 (P>0.05)；hK2检测PCa的敏感度、特异性、准确率分别为63.3%，90.0%，76.6%；血清hK2诊断PCa的ROC 曲线下面积为0.767（95%CI：0.642~0.891）；12例PCa患者手术前和手术后hK2比较差异有统计学意义（81.5±24.8ng/L vs 38.4±13.5ng/L，P<0.001）。［结论］ 血清hk2诊断PCa，可能可以提高其特异性，减少不必要的活检率，有望成为新的PCa检测指标预测高危人群。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the clinical significance of detection of serum human kallikrein 2(hK2) levels in patients with prostate cancer(PCa). ［Methods］ The levels of hK2 and prostate specific antigen(PSA) in 30 cases with PCa，30 cases with benign prostatichyperplasia(BPH) and 30 healthy person were detected by enzyme-linked immunosorbent assay(ELISA) and radioimmunoassay(RIA). Twelve cases with PCa after operation were followed up.［Results］ The levels of serum hK2 in PCa group(78.8±25.2ng/L) were significantly higher than that in BPH group(25.4±6.28ng/L) and healthy person(24.1±4.16ng/L)(P<0.001)，and there were no statistical difference between BPH group and healthy person(P>0.05). The sensitivity，specificity and accuracy of hK2 for PCa was 63.3%，90.0% and 76.6% respectively. The area under ROC curve of hK2 for PCa diagnosis was 0.767(95%CI：0.642~0.891). There was significant difference between in serum hK2 level of 12 patients before operation and after operation(81.5±24.8ng/L vs 38.4±13.5ng/L，P<0.001). ［Conclusions］ Detection of serum hK2 might improve the specificity and reduce unnecessary biopsies in diagnosis of PCa，it may be a new measured marker to predict high-risk population. |
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