| 周 源,韩开宝.必须重视肺癌术前病理学诊断[J].中国肿瘤,2014,23(9):714-719. |
| 必须重视肺癌术前病理学诊断 |
| To Pay More Attention to Preoperative Pathological Diagnosis for Lung Cancer |
| 投稿时间：2014-04-25 |
| DOI：10.11735/j.issn.1004-0242.2014.09.A003 |
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| 中文关键词: 肺肿瘤 小细胞肺癌 术前病理学诊断 新辅助化疗 外科手术 |
| 英文关键词:lung tumor preoperative pathological diagnosis neoadjuvant chemotherapy surgery |
| 基金项目: |
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| 摘要点击次数: 1944 |
| 全文下载次数: 981 |
| 中文摘要: |
| 摘 要：肺癌病理学诊断是肺癌诊断的金标准。 循证医学要求肺癌化疗、放疗、手术治疗前必须要获得准确的肺癌病理学诊断。新辅助化疗（neoadjuvant chemotherapy, NAC）1982年Frei首次提出，1985年NAC用于局限期小细胞肺癌。南京八一医院全军肿瘤研究中心在小细胞肺癌术前病理学诊断、NAC、肺癌术后多学科综合治疗方面连续探索研究20多年，结合国内外临床研究逐步形成一种实用有效的小细胞肺癌“链式治疗”新模式——先明确病理学诊断+ NAC（指有手术指征和手术条件者）+ 手术根治切除及纵隔淋巴结清扫+术后辅助化（放）疗+ 预防性全脑照射（PCI）+ 中医中药及免疫生物治疗等，使得肿瘤学行为特殊恶性程度极高的小细胞肺癌患者也能获得存活10年以上甚至27年的较为满意长期生存的好结果，由此有力印证：努力做好肺癌术前病理学诊断是必须的，也是有望做到的。 |
| 英文摘要: |
| Abstract：Pathological diagnosis of lung cancer is the “gold standard”, which should be obtained accurately before the treatments of lung cancer, such as surgery, chemotherapy and radiotherapy. It is the necessary premise and fundamental requirement for evidence-based medicine. In 1982, Freifirstly proposed neoadjuvant chemotherapy(NAC) and put forward the statement that NAC could be used in the treatment of limited SCLC in 1985. The Nanjing Ba-yi Hospital uninterruptedly committed to the research of early diagnosis of lung cancer and the treatments of SCLC including NAC, multidisciplinary treatment after surgery for more than 20 years. Combining with clinical research results, a novel complete chain therapy for SCLC was suggested——orderly, definite pathological diagnosis of SCLC + NAC (with surgical indications and no anti-indications in the health status) + radical resection and mediastinal lymph node cleaning + auxiliary chemotherapy / radiotherapy after operation + prophylactic cranial irradiation (PCI) + traditional Chinese medicine and biological immunotherapy and so on. A lot of SCLC patients have also got more satisfactory long-term survival more than 10 or 27 years. It is strongly confirmed that make accurate pathological diagnosis of lung cancer preoperatively is must be and hope to do. |
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