| 杜 辉,王国萍,王 纯.深圳市原住居民女性生殖道HPV感染[J].中国肿瘤,2014,23(11):908-912. |
| 深圳市原住居民女性生殖道HPV感染 |
| HPV Infection of Female Reproductive Tract and Prevalence of Cervical Cancer in Shenzhen Original Residents |
| 投稿时间：2014-04-24 |
| DOI：10.11735/j.issn.1004-0242.2014.11.A006 |
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| 中文关键词: 人乳头瘤病毒 宫颈上皮内瘤样病变 宫颈癌 深圳 |
| 英文关键词:human papillomavirus cervical intraepithelial neoplasia cervical cancer Shenzhen |
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| 中文摘要: |
| 摘 要：［目的］ 了解深圳市原住居民女性人群的生殖道高危型人乳头瘤病毒(HPV)感染现状、宫颈上皮内瘤样病变(CIN)和宫颈癌的现患率。［方法］ 2009年6月至2009年10月在深圳市龙岗区坑梓街道办事处辖区25～59岁、3年内未做过宫颈癌筛查的原住居民女性进行整群抽样，并以同一辖区外来移民女性为对照。所有接受筛查女性均行宫颈液基细胞学检查及第二代杂交捕获技术（hybrid captureⅡ，HC-Ⅱ）高危型HPV检测。HPV阳性和/或细胞学≥ASCUS的女性行阴道镜检查和活检。［结果］ 共有942名原住居民妇女和1183名外来移民女性参加了本次调查。原住居民与外来移民妇女HPV阳性率分别为16.9%和11.8%（P<0.05）。原住居民妇女CIN现患率为9.7%，其中CIN Ⅱ及以上病变现患率为6.3%，外来移民CIN现患率5.1%，其中CINⅡ及以上病变现患率为2.6%。原住居民妇女CIN 和CINⅡ及以上病变现患率均明显高于外来移民（P<0.001），尤以30～39岁年龄组最为明显。［结论］ 30～39岁年龄组妇女HPV感染和CIN现患率均较高，应作为宫颈癌防治的重点监测对象。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the prevalence of HPV infection of female reproductive tract，cervical intraepithelial neoplasia (CIN) and cervical cancer in Shenzhen original residents. ［Methods］ From June 2009 to October 2009，the original women from Kengzi street，Longgang subdistrict，Shenzhen city with 25~59 years-old and without cervical cancer screening <3 years were selected by cluster sampling. The migrant women in the same area as the control. The ThinPrep cytology and the HC-Ⅱ HPV assay were processed. All women with ≥ASCUS and/or a positive HC-Ⅱ HPV test were asked to return for colposcopy.［Results］ A total of 942 original women and 1183 migrant women participated in the study. The HPV positive rate in original people and migrant women were 16.9% and 11.8% respectively(P<0.05). The prevalence of cervical intraepithelial neoplasia(CIN) and ≥CINⅡ in original women was 9.7%，6.3% respectively，and in migrant women was 5.1%，2.6% respectively. The prevalence of CIN and ≥CINⅡ in original women were significantly higher than that in migrant women(P<0.001)，particularly in the 30 to 39 years groups. ［Conclusion］ The prevalence of HPV infection and CIN were both high in original women aged from 30 to 39，so this age group women should be focus on monitoring. |
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