| 江秀娟,牛继国,呼永华.地塞米松对非小细胞肺癌化疗患者HIF-1α[J].中国肿瘤,2015,24(1):73-75. |
| 地塞米松对非小细胞肺癌化疗患者HIF-1α |
| Effect of Dexamethasone on Level of Hypoxia Inducible Factor-1α and Vascular Endothelial Growth Factor in Patients with Non-small Cell Lung Cancer |
| 投稿时间：2014-09-04 |
| DOI：10.11735/j.issn.1004-0242.2015.01.A016 |
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| 中文关键词: 非小细胞肺癌 地塞米松 低氧诱导因子-1α 血管内皮生长因子 |
| 英文关键词:NSCLC dexamethasone HIF-1α VEGF |
| 基金项目:甘肃省科技厅技术研究与开发专项计划项目（1105TCYa019） |
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| 中文摘要: |
| 摘 要：［目的］ 探讨地塞米松对非小细胞肺癌化疗患者低氧诱导因子-1α（HIF-1α） 和血管内皮生长因子（VEGF）表达的影响。［方法］ 97例非小细胞肺癌患者随机分为单纯化疗组和地塞米松辅助化疗组，采用酶联免疫吸附试验（ELISA）分别测定两组患者治疗前及治疗后的血清 HIF-1α、VEGF水平。［结果］ 治疗前两组患者HIF-1α及VEGF水平均未见统计学差异(P>0.05)；治疗后地塞米松辅助化疗组HIF-1α及VEGF水平明显低于单纯化疗组(P<0.05)。地塞米松辅助化疗组有效率（44.00%）明显高于单纯化疗组（27.79%）（χ2=6.304，P<0.05）。［结论］ 地塞米松使非小细胞肺癌患者HIF-1α、VEGF水平下降，提高了化疗近期效果。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the effect of dexamethasone on level of hypoxia inducible factors-1α(HIF-1α) and vascular endothelial growth factor (VEGF) in chemotherapy of non-small-cell lung cancer( NSCLC ). ［Methods］ A total of 97 cases with NSCLC were divided into chemotherapy group and combined chemotherapy with dexamethasone . HIF-1α and VEGF level in two groups were detected by enzyme-linked immune sorbent assay in pre - and post-treatment. ［Results］ The HIF-1α and VEGF level were not significant difference in two groups before treatment(P>0.05). After treatment，the HIF-1α and VEGF level in combined chemotherapy with dexamethasone was lower than that in alone chemotherapy group with significant difference (P<0.05) .The effective rate in combined chemotherapy with dexamethasone was 44.00%，which was higher than that in 27.79% in chemotherapy group(χ2=6.304，P<0.05). ［Conclusion］ Dexamethasone can decrease the HIF-1α and VEGF level in patients with NSCLC，improved chemotherapy efficacy. |
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