| 段仙芝,宋艳波,王少明.宫颈液基细胞学结果与高危型人乳头瘤病毒的相关性[J].中国肿瘤,2015,24(1):76-80. |
| 宫颈液基细胞学结果与高危型人乳头瘤病毒的相关性 |
| Correlation of the Results of Cervical Liquid-Based Cytology and High-Risk Human Papillomavirus Infection |
| 投稿时间：2014-06-30 |
| DOI：10.11735/j.issn.1004-0242.2015.01.A017 |
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| 中文关键词: 液基细胞学 Cervista HPV 宫颈癌 筛查 |
| 英文关键词:liquid-based cytology Cervista HPV cervical cancer screening |
| 基金项目:卫生部医药卫生科技发展计划［卫技中201043号］ |
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| 中文摘要: |
| 摘 要：［目的］ 探讨宫颈液基细胞学结果和高危型人乳头瘤病毒（HPV）的相关性，为不同卫生资源地区宫颈癌初筛方法的选择提供科学数据。［方法］ 2012~2013年选取内蒙古地区20~69岁女性25 731名，采用新柏氏液基细胞学技术开展筛查。并采用Cervista方法进行HPV检测。对细胞学异常或HPV阳性者召回行阴道镜检查。［结果］ 液基细胞学异常率为5.8%，HPV总阳性率为24.5%，A9型为最常见的HPV感染型别，感染率为7.8%。HPV阳性率和A9型阳性率均与细胞学病变级别显著性正相关，相关系数分别为0.253和0.226（P<0.001）。［结论］ Cervista HPV检测技术是宫颈癌筛查的有效手段，通过该技术对宫颈癌进行初筛并对高危人群分流管理，可扩大筛查覆盖面，使更多百姓受益。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the correlation of the results of liquid-based cytology and high-risk human papillomavirus(HPV) infection，and to provide scientific data for selecting primary screening technologies for cervical cancer in various economic areas.［Methods］ From 2012 to 2013，a total of 25731 women aged 20~69 in Inner Mongolia were screened by Thinprep liquid-based cytology for cervical cancer. The samples were tested for HPV infection by Cervista method. Those women with abnormal cytological results or HPV infection were referred to colposcopy.［Results］ The positivity of cytology and HPV infection was 5.8% and 24.5%，respectively. A9 group were the most common infective HPV types with a positive rate of 7.8%. Both the total HPV infection rate and A9 group HPV infection rate were positively associated with the grade of cytological abnormity，with a correlation coefficient of 0.253 and 0.226，respectively (P<0.001).［Conclusion］ Cervista HPV detection is an effective method for primary screening cervical cancer and for the management of high-risk population，and it can be used in different areas to expand the coverage of screening. |
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