| 刘 鹏,刘 宏,张文峰.不同部位食管癌放射治疗对机体免疫功能的影响[J].中国肿瘤,2015,24(4):344-348. |
| 不同部位食管癌放射治疗对机体免疫功能的影响 |
| The Effect of Radiotherapy on Immunity in Patients with Different Parts of Esophageal Cancer |
| 投稿时间：2014-07-31 |
| DOI：10.11735/j.issn.1004-0242.2015.04.A019 |
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| 中文关键词: 食管癌 放射治疗 免疫功能 免疫抑制 |
| 英文关键词:esophageal cancer radiotherapy immunity immunosuppression |
| 基金项目:青岛市公共领域科技支撑计划项目（12-1-3-3-（3）-nsh） |
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| 摘要点击次数: 2020 |
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| 中文摘要: |
| 摘 要：［目的］ 探讨不同部位食管癌患者放射治疗对机体免疫功能的影响。［方法］ 收集行放射治疗的109例食管癌患者资料，其中上段食管癌35例，中段食管癌42例，下段食管癌32例。检测所有患者放疗前、放疗后4周、6周及10周外周血淋巴细胞计数(lymphocyte count，LC)及CD4+T、CD8+T、CD4/CD8、自然杀伤细胞（natural killer cells，NK）水平，对三组不同部位食管癌患者上述免疫指标进行比较分析。［结果］ 放疗后食管癌患者各时间点全血中LC、CD4+T、CD4/CD8、NK比例均较放疗前下降，且下段组各时间点全血中LC、CD4+T、CD4/CD8、NK比例均低于中段组和上段组（P均<0.05）；CD8+T较放疗前升高，且下段组各时间点CD8+T比例均高于中段组和上段组（P<0.05 ）。［结论］ 食管癌患者放射治疗后出现免疫功能抑制，以下段食管癌最为严重。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the effect of radiotherapy on immunity in patients with different parts of esophageal cancer. ［Methods］ The clinical data of 109 cases with esophageal cancer (35 cases of upper esophageal cancer，42 cases of middle esophageal cancer and 32 cases of lower esophageal cancer) was collected. Immune indicators such as lymphocyte count (LC)，natural killer cells (NK)，CD4+T，CD8+T and CD4/CD8 were detected before radiotherapy and at 4th week，6th week and 10th week postradiotherapy in all patients，and these immune indicators were compared among the three groups.［Results］ Counts of total lymphocytes，NK cells，CD4+T and CD4/CD8 of postradiotherapy were reduced significantly than those of preradiotherapy. Counts of immune parameters of postradiotherapy in lower esophageal cancer group were reduced significantly than those of middle and upper esophageal cancer groups at each time point（all P<0.05）.CD8+T of postradiotherapy increased significantly than that of preradiotherapy，while the lower esophageal cancer group increased significantly than that of middle and upper esophageal cancer groups(all P<0.05). ［Conclusion］ The immunity in patients with esophageal cancer after radiotherapy is inhibited，and the lower esophageal cancer patients are most serious. |
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