| 中文关键词: 肺癌 干细胞 上皮间叶转化 |
| 英文关键词:lung cancer stem cells epithelial mesenchymal transition |
| 基金项目:国家自然科学基金资助（81173450） |
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| 摘要点击次数: 1830 |
| 全文下载次数: 917 |
| 中文摘要: |
| 摘 要：肺癌干细胞是肺癌组织中含量很少的一类细胞亚群，在肺癌的化疗耐药以及侵袭转移中发挥着重要的作用。肺癌干细胞也可能是肺癌的初始细胞，肺上皮的祖细胞或干细胞通过上皮间叶转化等途径获得干细胞特性和侵袭能力。肺癌干细胞有相对特异的表面标志和与增殖、分化相关的信号通路，通过各种途径对肺癌干细胞进行杀伤或抑制将会对肺癌治疗产生积极的影响。 |
| 英文摘要: |
| Abstract：Lung cancer stem cells which are a cell subset with few subpopulation in lung cancer tissues and play important roles in lung cancer chemothetapy resistance and metastasis. In addition，the lung cancer stem cells may be the initial cells of lung cancer. Lung epithelial progenitor cells or stem cells may obtain stem cell characteristics and invasion ability by epithelial mesenchymal transition. Lung cancer stem cells have relatively specific surface markers and signaling pathways associated with cell proliferation and differentiation. Killing and inhibiting lung cancer stem cells througe various ways may have positive effects on the treatment of lung cancer. |
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