| 宋晓庆,邓姝哲,邱慧磊.MACC1和c-Met蛋白在胃印戒细胞癌中的表达及意义[J].中国肿瘤,2015,24(7):607-612. |
| MACC1和c-Met蛋白在胃印戒细胞癌中的表达及意义 |
| Expression of MACC1 and c-Met Proteins in Signet Ring Cell Carcinoma and Its Significance |
| 投稿时间：2014-11-19 |
| DOI：10.11735/j.issn.1004-0242.2015.07.A015 |
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| 中文关键词: 胃印戒细胞癌 结肠癌转移相关基因1 肝细胞生长因子受体 浸润 转移 |
| 英文关键词:signet ring cell carcinoma MACC1 c-Met invasion metastasis |
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| 摘要点击次数: 2003 |
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| 中文摘要: |
| 摘 要：［目的］探讨结肠癌转移相关基因1（metastasis-associated in colon cancer 1，MACC1）和肝细胞生长因子受体（hepatocyte growth factor receptor，c-Met）在胃印戒细胞癌（signet ring cell carcinoma，SRCC）组织中的表达及其与临床病理特征的相关性。［方法］应用免疫组化法检测80例SRCC组织及其对应癌旁组织和25例癌前病变组织中MACC1和c-Met蛋白的表达情况，统计学分析MACC1和c-Met表达水平与临床病理特征的关系。［结果］MACC1和c-Met在SRCC组织中的阳性率均明显高于癌旁组织和癌前病变组织（P＜0.05）。MACC1和c-Met阳性率均与肿瘤浸润深度、TNM分期、淋巴结转移和腹膜转移相关（P<0.05），而与年龄、性别、肿物部位、大小、CEA和CA199无统计学意义相关（P＞0.05）。SRCC组织中MACC1和c-Met的表达呈正相关（r=0.301，P=0.007)。［结论］MACC1和c-Met在SRCC的侵袭和转移过程中发挥重要作用，有望成为SRCC预后的标志及潜在治疗靶点。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the expression of metastasis-associated in colon cancer 1（MACC1）and hepatocyte growth factor receptor (c-Met) in signet ring cell carcinoma（SRCC ） and its relationship with clinical features. ［Methods］ The expression of MACC1 and c-Met in 80 cases of SRCC，80 cases of paracancerous lesion and 25 cases of para-cancerous lesion was detected with immunohistochemistry. The correlation of the expression of MACC1 and c-Met in SRCC with clinicopathological parameters was analyzed. ［Results］ The positive expression rates of MACC1 and c-Met proteins in SRCC were significantly increased than those in precancerous lesion and para-cancerous(P<0.05). MACC1 and c-Met expression correlated to depth of tumor invasion，TNM stage，lymph node metastasis and peritoneal metastasis(P＜0.05)，but did not correlated to gender，age，tumor size，tumor location，CEA and CA199. In addition，MACC1 expression was positively correlated with c-Met(r=0.301，P=0.007). ［Conclusions］ MACC1 and c-Met play an important role in the invasion and metastasis of SRCC. MACC1 and c-Met could consider as biomarkers and new targets for SRCC therapy. |
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