| 谢 欣,许慧琳,严玉洁.低剂量螺旋CT对7496名社区肺癌高危人群的筛查研究[J].中国肿瘤,2015,24(10):811-814. |
| 低剂量螺旋CT对7496名社区肺癌高危人群的筛查研究 |
| Lung Cancer Screening Using Low-dose Computed Tomography in 7496 Community Residents with High-risk |
| 投稿时间：2015-05-06 |
| DOI：10.11735/j.issn.1004-0242.2015.10.A002 |
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| 中文关键词: 肺癌 低剂量螺旋CT 筛查 高危人群 |
| 英文关键词:lung cancer tomography screening high risk group |
| 基金项目:上海市闵行区卫生与计划生育委员会科研项目（2014MW33） |
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| 中文摘要: |
| 摘 要：［目的］ 探讨低剂量螺旋CT（LDCT）对社区肺癌高危人群的筛查效果。 ［方法］ 在社区招募7496名肺癌高危人群进行LDCT筛查。肺癌高危人群定义为年龄40岁以上，并且具有下列任何一项者：20包年以上的吸烟史、肺癌家族史、肺部既往病史（慢性阻塞性肺病、肺结核）、职业接触史（石棉、氡、砷、铬、镍接触史）。以发现至少一个≥4 mm非钙化结节为LDCT筛查的阳性结果。［结果］ 7496名肺癌高危人群进行LDCT肺癌筛查，非钙化结节≥4 mm 者共1057名（14.1%）。年龄≥55岁的高危人群结节阳性率显著高于年龄<55岁者（14.9% vs 9.7%；χ2=22.27，P<0.001）。筛查出肺癌33例，占结节阳性者的3.1%，肺癌检出率为0.44%。共确诊21例非小细胞肺癌，其中0~Ⅰ期11例，早期诊断率为52.4%。［结论］ LDCT肺癌筛查有助于提高肺癌的早期诊断率和非钙化结节的检出率，尤以55岁以上人群值得推广。 |
| 英文摘要: |
| Abstract：［Purpose］ To explore the effect of low-dose computed tomography (LDCT) screening for lung cancer in a high risk group from local community. ［Methods］ The 7496 community residents with high risk for lung cancer were enrolled. The person with high risk of lung cancer was defined as someone with age≥40，at least having one of the four requirements：a smoking history of at least 20 pack years，a family history of lung cancer，a history of lung disease，and a history of occupational hazardous exposure，such as asbestos，radon，arsenic，chromium，nickel. LDCT scans that revealed any non-calcified nodule measuring at least 4mm was classified as positive outcomes. ［Results］ A total of 7496 persons at high risk for lung cancer underwent screening，with a result of 1057(14.1%) participants having at least one non-calcified nodule with a diameter ≥4 mm. The positive rate in subjects more than 55 years old were higher than that of those less than 55 years old (14.9% vs 9.7%; χ2=22.27，P<0.001). A total of 33 lung cancers were diagnosed after a positive LDCT test. The detection rate of lung cancer was 3.1% in the group with a positive LDCT test and 0.44% in the whole risk group. A total of 21 non-small cell lung cancer cases，with 11 cases in stage 0～Ⅰ，were conformed in the screening trial and the percentage of early lung cancer was 52.4%. ［Conclusions］ The LDCT screening may be helpful for early detection for lung cancer and positive non-calcified nodules，especially in high risk group aged more than 55 years old. |
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