| 林明政,沈国栋,沈 干.胃癌耐药相关抑癌基因的相互作用[J].中国肿瘤,2015,24(10):864-870. |
| 胃癌耐药相关抑癌基因的相互作用 |
| Association between Tumor Suppressor Genes and Drug Resistance in Gastric Cancer |
| 投稿时间：2015-04-28 |
| DOI：10.11735/j.issn.1004-0242.2015.10.A014 |
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| 中文关键词: 胃癌 抑癌基因 化疗耐药 生物信息学 |
| 英文关键词:gastric cancer tumor suppressor gene drug resistance bioinformatics |
| 基金项目:安徽省自然科学基金(1408085MH167)，安徽省科技计划项目(1301042094) |
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| 摘要点击次数: 1863 |
| 全文下载次数: 860 |
| 中文摘要: |
| 摘 要：大量研究发现抑癌基因与包括胃癌在内的多种人体肿瘤的化疗耐药密切相关。因此，深入研究胃癌耐药相关抑癌基因的作用机制对进一步提高胃癌的诊疗具有重要意义。全文分析14种与胃癌耐药相关的抑癌基因，并基于生物信息学技术预测分析这14种抑癌基因及其表达蛋白之间存在的相互作用及生物学功能。 |
| 英文摘要: |
| Abstract：Previous studies showed that tumor suppressor genes(TSGs) had intimate relationship with the drug resistance in several kinds of tumors，including gastric cancer. Therefore，lucubrating the mechanism of TSGs has great significance to improve the quality of diagnosis and treatment for gastric cancer. In this article，14 TSGs correlated with drug resistance in gastric cancer are analyzed，as well as gene/protein interactions and biological processes of these TSGs . |
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