| 刘 霏,李浩然,杨 莉.DNA损伤修复相关基因Polζ、ERCC1、ERCC2[J].中国肿瘤,2015,24(10):875-880. |
| DNA损伤修复相关基因Polζ、ERCC1、ERCC2 |
| The Clinical Significance of Polζ，ERCC1，ERCC2 and RAD52 Expression in Cervical Cancer Tissues |
| 投稿时间：2015-06-14 |
| DOI：10.11735/j.issn.1004-0242.2015.10.A016 |
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| 中文关键词: 宫颈癌 预后 Polζ ERCC1 ERCC2 RAD52 |
| 英文关键词:cervical cancer prognosis Polζ ERCC1 ERCC2 RAD52 |
| 基金项目:国家自然科学基金青年科学基金（81202050） |
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| 摘要点击次数: 2091 |
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| 中文摘要: |
| 摘 要：［目的］ 评价DNA损伤修复相关基因在宫颈癌组织中的表达及其临床意义。［方法］ 纳入2008~2009年在复旦大学附属肿瘤医院行根治性手术并辅助同步放化疗的113例宫颈鳞状细胞癌患者，采用免疫组化法检测DNA损伤修复相关基因（Polζ，ERCC1，ERCC2和RAD52）在石蜡包埋组织中的蛋白表达水平。［结果］ Polζ，ERCC1，ERCC2和RAD52的阳性表达率分别为22.1%，46.0%，48.7%和20.4%。Kaplan-Meier 生存分析表明Polζ蛋白表达阳性的患者无进展生存期更短（32个月vs 34个月，P=0.008）。多因素生存分析显示Polζ是肿瘤复发的重要因素（adjusted HR=7.79，95%CI：2.21~27.52，P=0.001）。［结论］ Polζ可作为宫颈癌判断预后的预测因素，这可能是由于宫颈癌患者潜在的放化疗抵抗导致的，该机制值得进一步研究。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the expression profiles of multiple DNA damage repair genes Polζ，ERCC1，ERCC2 and RAD52 in cervical cancer tissues and its clinical significance. ［Methods］ A total of 113 patients with squamous cell carcinoma of cervical cancer，who had adjuvant concurrent chemoradiation therapy after radical surgery treated at Fudan University Shanghai Cancer Center between 2008 and 2009 were enrolled，and immunohistochemistry was used to test Polζ，ERCC1，ERCC2 and RAD52 protein expression in paraffin?鄄embedded tissues. ［Results］ The positive expression of Polζ，ERCC1，ERCC2 and RAD52 was 22.1%，46.0%，48.7% and 20.4%，respectively. Kaplan?鄄meier survival showed that the patients with Polζ?鄄positive expression had a significantly shorter progression?鄄free survival(32 months vs 34 months，P=0.008). Multivariate Cox proportional hazards regression analysis revealed that Polζ protein expression(adjusted HR=7.79，95%CI：2.21~27.52，P=0.001) was a significant predictor for recurrence/metastasis. ［Conclusions］ Polζ expression can serve as the predictor for poor prognosis in cervical cancer，which might due to the chemoradiation resistance of cervical cancer patients. The exact mechanism needs further research. |
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