| 李 姗,宗丽菊,孟丽华.子宫上皮细胞稳定性FH检测在诊断宫颈癌及癌前病变中的临床意义[J].中国肿瘤,2015,24(10):881-883. |
| 子宫上皮细胞稳定性FH检测在诊断宫颈癌及癌前病变中的临床意义 |
| The Clinical Significance of Uterine Epithelial Cells Stability FH Test in Cervical Cancer and Precancerous Lesions |
| 投稿时间：2015-07-08 |
| DOI：10.11735/j.issn.1004-0242.2015.10.A017 |
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| 中文关键词: 子宫上皮细胞稳定性FH检测 宫颈癌 游离亚铁血红素 敏感度 特异性 |
| 英文关键词:uterine epithelial cells stability FH test cervical cancer cervical precancerous lesions free heme sensitivity specificity |
| 基金项目:山东省科技发展计划项目(2014GGH218029)，山东大学齐鲁医院科研基金资助项目（2015QLMS48） |
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| 中文摘要: |
| 摘 要：［目的］ 评价子宫上皮细胞稳定性FH检测技术在诊断宫颈癌及癌前病变中的临床意义。［方法］ 对经病理学诊断的宫颈上皮内瘤变(CIN)、宫颈癌、宫颈良性病变及宫颈正常的女性共540例，进行子宫上皮细胞稳定性FH检测和宫颈细胞学（TCT）检查，比较两种检测方法的敏感度 及特异性。［结果］ 子宫上皮细胞稳定性FH检测诊断CIN2~3、宫颈癌的敏感度分别为 76.3% (95%CI：70.3%~82.2%)、94.4% (95%CI：89.1%~99.7%)，与TCT检测的敏感度差异无统计学意义。子宫上皮细胞稳定性FH检测诊断宫颈病变的特异性为64.4% (95%CI：58.7%~70.2%)，低于TCT检测的特异性。［结论］ 子宫上皮细胞稳定性FH检测对诊断宫颈病变具有较高的敏感度，且具有快速、简便、经济的特点，适用于偏远贫困地区女性的宫颈癌筛查。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the clinical significance of uterine epithelial cells stability FH test in cervical cancer and precancerous lesions. ［Methods］ A total of 540 women pathologically diagnosed with cervical intraepithelial neoplasia(CIN)，cervical cancer，cervical benign lesions and normal cervix were detected by uterine epithelial cells stability FH test and Thin-prep cytology test (TCT) . The sensitivity and specificity of Thin-prep cytology test (TCT) and uterine epithelial cells stability FH test for cervical lesions were compared. ［Results］ The sensitivity of uterine epithelial cells stability FH test in detecting CIN，cervical cancer were 76.3%(95%CI：70.3%~82.2%)，94.4%(95%CI：89.1%~99.7%)，respectively，which was no significant difference compared with TCT test. The specificity of uterine epithelial cells stability FH test in detecting cervical lesions was 64.4% (95%CI：58.7%~70.2%)，which was lower than that in TCT test. ［Conclusion］ Uterine epithelial cells stability FH test，characterized as is rapid，simple and economical，has a high sensitivity in detecting cervical lesions，and can be used for cervical cancer screening，especially for women in remote poverty-stricken areas. |
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