| 刘 翔,凌志强.NDRG1/3在肿瘤中的作用研究进展[J].中国肿瘤,2015,24(12):1018-1021. |
| NDRG1/3在肿瘤中的作用研究进展 |
| Research Progress in NDRG1 and NDRG3 in Human Malignancies |
| 投稿时间：2015-05-26 |
| DOI：10.11735/j.issn.1004-0242.2015.12.A013 |
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| 中文关键词: 肿瘤 NDRG 细胞分化 肿瘤转移 |
| 英文关键词:neoplasm N-myc downstream regulated gene cell differentiation neoplasm metastasis |
| 基金项目:浙江省自然基金重点项目（LZ13H160002），浙江省卫生高层次创新人才培养工程项目，浙江省新世纪151人才工程重点资助项目 |
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| 中文摘要: |
| 摘 要：N-myc下游调节基因（N-myc downstream regulated gene，NDRG）家族由NDRG1-4 4个成员组成，相互之间具有很高的氨基酸同源性。NDRG家族成员在不同物种间表达具有高度保守性，而在不同组织间分布有较大差异。近年来，研究发现NDRG家族成员在多种肿瘤中表达异常，并与肿瘤进展和预后相关，是潜在的肿瘤诊断、预后评价标志物和治疗靶标。 |
| 英文摘要: |
| Abstract：The N-myc downstream regulated gene (NDRG) family contains 4 members，NDRG1~4，which share a high degree of amino acid identity. NDRG family is well conserved through evolution，but show distinct tissue distribution. In recent years，it was reported that members of NDRG family were aberrant expression in various of human malignancies and involved progress and prognosis of cancer. Thus NDRG is considered to be a potential biomarker for diagnosis and prognosis evaluation，targeted therapy. |
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