| 傅志勤,陈雅卿.术前血清C-反应蛋白水平在卵巢癌患者预后判断中的价值[J].中国肿瘤,2016,25(4):324-328. |
| 术前血清C-反应蛋白水平在卵巢癌患者预后判断中的价值 |
| Prognostic Value of Preoperative Serum C-Reactive Protein in Patients with Ovarian Cancer |
| 投稿时间：2015-12-11 |
| DOI：10.11735/j.issn.1004-0242.2016.04.A016 |
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| 中文关键词: C-反应蛋白 卵巢癌 临床病理参数 预后 |
| 英文关键词:C-reactive protein ovarian cancer clinical pathological parameters prognosis |
| 基金项目:浙江省自然基金（Y15H160030） |
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| 摘要点击次数: 1809 |
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| 中文摘要: |
| 摘 要：［目的］ 探讨术前卵巢癌血清中C-反应蛋白（C-reactive protein，CRP）与临床病理参数及预后的关系。［方法］ 回顾性分析2008年1月 至 2014年4月手术的187例初治卵巢癌患者的病例资料，分析术前 CRP 值与年龄、国际妇产科联盟（International Federation of Gynecologists and Obstetricians，FIGO）分期、组织分级、腹水量及术后残余病灶大小的关系。 ［结果］ 82例（44.09％）卵巢癌患者术前血清 CRP 值为阳性，平均值为26.41 mg/L。CRP 值与 FIGO 分期（P<0.05），残余肿瘤大小（P<0.01）和腹水量（P<0.01）显著性相关。术前血清 CRP 阳性率与腹水量相关（P<0.01），与年龄、组织分级和 FIGO 分期无关。CRP 阳性的卵巢癌患者5年生存率（62.3%）低于 CRP 阴性的患者（79.6%）（P<0.01）。［结论］ 检测术前血清 CRP 值对卵巢癌病情严重程度及预后有重要临床意义。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the correlations between preoperative C-reactive protein（CRP) serum concentration and the clinical pathological parameters as well as prognostic value in patients with ovarian cancer. ［Methods］ A total of 187 ovarian cancer patients were selected from January 2008 to April 2014，and clinicopathological and C-reactive protein data were analyzed. Correlation between CRP expression and age，International Federation of Gynecologists and Obstetricians（FIGO) staging，histological grade，ascites and size of postoperative residual lesions were evaluated. ［Results］ Eighty-two（44.09%) cases of ovarian cancer were CRP-positive with an average serum CRP concentration of 26.41mg/L. Non-parametric and multivariate analyses showed significant correlation between CRP concentrations and FIGO staging（P<0.05），residual tumor（P<0.01） and ascites（P<0.01）. The positive rate of preoperative serum CRP was positively associated with ascites（P<0.01），but not associated with age，tissue grade and FIGO staging. The five year survival rate of CRP positive patients with ovarian cancer(62.3%) was significant lower than that of the CRP negative patients（79.6%）（P<0.01）. ［Conclusion］ Detecting the serum CRP concentration may be useful in clinical value for evaluating the disease severity and prognosis in patients with ovarian cancer. |
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