| 张雨晴,马 莉,贺宇彤.2001~2010年中国胰腺神经内分泌肿瘤的临床流行病学特征分析[J].中国肿瘤,2016,25(5):329-333. |
| 2001~2010年中国胰腺神经内分泌肿瘤的临床流行病学特征分析 |
| Clinical and Epidemiological Features of Pancreatic Neuroendocrine Neoplasm in China，2001~2010 |
| 投稿时间：2015-12-20 |
| DOI：10.11735/j.issn.1004-0242.2016.05.A001 |
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| 中文关键词: 胰腺神经内分泌肿瘤 回顾性研究 多中心 临床流行病学 |
| 英文关键词:pancreatic neuroendocrine neoplasm retrospective study multi-center clinical epidemiology |
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| 中文摘要: |
| 摘 要：［目的］ 分析中国2001~2010年胰腺神经内分泌肿瘤患者的流行病学特征。［方法］ 将中国大陆按传统的习惯分为七个区，每个大区选取至少一家肿瘤医院和综合医院。收集医院2001~2010年间所有经病理确诊为胰腺神经内分泌肿瘤的病例信息，摘录至病例信息收集表并进行统计分析。［结果］ 研究共纳入中国七个地理大区23家医院共633例胰腺神经内分泌肿瘤患者，平均年龄45.7±14.0岁，男性占41.2%。10年间病例数持续增加，且以低级别早期肿瘤的增加为主。功能性胰腺神经内分泌肿瘤占57.1%。其中，出现Whipple三联征的患者占46.8%。诊断时局限于胰腺内（70.0%）、G1/G2级(57.8%)的患者较多。临床上最常用的影像学检查手段为超声（78.2%）和CT（85.9%）。手术是最主要的治疗方式，92.4%的患者接受了手术切除。［结论］ 中国胰腺神经内分泌肿瘤患者的诊断年龄较早，分期及分级较低，且10年间以低级别病变的检出增加为主。传统影像学手段对于肿瘤的检出率较高，手术治疗为主要的治疗方式。 |
| 英文摘要: |
| Abstract：［Purpose］ To analyze the clinical and epidemiological features of pancreatic neuroendocrine neoplasm in China，2001~2010. ［Method］ At least one general hospital and one cancer hospital at tertiary level were selected in each of the seven geographic regions in China. Patients with pathologically confirmed pancreatic neuroendocrine neoplasm admitted in these hospitals during 2001~2010 were selected and the data were collected based on the case report form. ［Results］ Clinical data of 633 eligible cases of pancreatic neuroendocrine neoplasm from 23 hospitals，including 261 males and 372 females with a mean age of 45.7±14.0 years，were analyzed. The case number was increasing in 10 years，especially for early-stage tumors. The functional pancreatic neuroendocrine tumors accounted for 57.1% of total cases，and Whipple triad was found in 46.8% of patients. There were 70.0% of pancreatic neuroendocrine neoplasms confined to the pancreas and 57.8% in G1/G2 grade when diagnosed. Ultrasound and CT were the most common imaging examinations and were performed on 78.2% and 85.9% patients. Surgery was performed on 92.4% patients. ［Conclusions］ Patients with pancreatic neuroendocrine neoplasm were diagnosed at a relatively early age with lower stage and grade in China. The increasing trend of case number was mainly due to the increase of early lesions. The conventional imaging methods are well performed with satisfied detection rates. Surgery remains as the main modality of cure. |
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