| 宋春丽,呼君瑜,李美艳.FHIT、C-myc在宫颈癌中的表达及其与高危型HPV感染的相关性[J].中国肿瘤,2016,25(5):395-399. |
| FHIT、C-myc在宫颈癌中的表达及其与高危型HPV感染的相关性 |
| Expression of FHIT and C-myc in Cervical Cancer and Its Correlation with High-Risk HPV Infection |
| 投稿时间：2015-11-21 |
| DOI：10.11735/j.issn.1004-0242.2016.05.A015 |
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| 中文关键词: FHIT C-myc HR-HPV 宫颈癌 |
| 英文关键词:FHIT C-myc HR-HPV cervical cancer |
| 基金项目:邯郸市科技局科技计划项目（1323108087-13） |
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| 摘要点击次数: 1905 |
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| 中文摘要: |
| 摘 要：［目的］ 探讨脆性组氨酸三联体（fragile histidine traid，FHIT）、C-myc在宫颈癌中的表达及与高危型人乳头状瘤病毒（high-risk HPV，HR-HPV）感染的相关性。［方法］ 采用免疫组化SP法检测50例宫颈癌组织(cervical cancer)、70例宫颈上皮内瘤变(CIN)和30例正常宫颈组织中FHIT和C-myc的表达情况，并分析其与宫颈癌临床病理特征的关系。采用HC-Ⅱ法检测HR-HPV感染情况。［结果］ (1) 正常宫颈组织、CIN组及宫颈癌组中FHIT的阳性表达率分别为93.3%、67.1%、22.0%(P<0.05)，C-myc的阳性表达率分别为16.7%、47.1%、76.0%(P<0.05)。(2)FHIT表达与FIGO分期、病理学分级相关 (P<0.05)，C-myc表达与FIGO分期相关(P<0.05)。(3) HR-HPV 在正常宫颈组织、CIN组及宫颈癌组中的感染率分别为3.33%、28.57%、84.0%。FHIT与C-myc的表达呈负相关（r=-0.622，P<0.05），FHIT表达与HR-HPV感染呈负相关，C-myc表达与HR-HPV感染呈正相关。［结论］ 联合检测FHIT、C-myc表达以及HR-HPV感染情况，可能可为早期宫颈癌诊断提供参考依据。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the expression of fragile histidine triplet(FHIT) and C-myc in cervical cancer and its correlation with high-risk HPV(HR-HPV) infection. ［Methods］ The expression of FHIT and C-myc was detected by immunohistochemical SP method in 50 specimens of cervical cancer，70 specimens of cervical intraepithelial neoplasm(CIN) and 30 specimens of normal cervical tissue. HR-HPV infection was detected by HC-Ⅱ method. The relationship of FHIT and C-myc expression with clinicopathological features of cervical cancer and HR-HPV infection was analyzed. ［Results］ The positive expression rate of FHIT and C-myc in normal cervical tissue，CIN and cervical cancer was 93.3%，67.1%，22.0%，and 16.7%，47.1% and 76.0%，respectively(P<0.05). The expression of FHIT was correlated with FIGO stage and pathological classification of cervical cancer(P<0.05). The expression of C-myc was correlated with FIGO stage(P<0.05). The infection rate of HR-HPV in normal cervical tissue，CIN and cervical cancer was 3.33%，28.57%，84.0%，respectively. FHIT expression was negatively correlated with C-myc expression(r=-0.622，P<0.05). FHIT expression was negatively correlated with HR-HPV infection(P<0.05)，while C-myc expression was positively correlated with HR-HPV infection(P<0.05). ［Conclusion］ The combined detection of FHIT，C-myc expression and HR HPV infection may provide important information for early diagnosis of cervical cancer. |
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