刘立梅,高清平,王琼玉.嵌合型抗原受体T细胞疗法的研究进展[J].中国肿瘤,2016,25(6):453-458. |
嵌合型抗原受体T细胞疗法的研究进展 |
Research Progression in Chimeric Antigen Receptor T Cell Therapy |
投稿时间:2015-10-26 |
DOI:10.11735/j.issn.1004-0242.2016.06.A011 |
|
 |
中文关键词: 嵌合型抗原受体 过继性细胞免疫治疗 肿瘤相关性抗原 协同刺激 |
英文关键词:chimeric antigen receptor adoptive immunotherapy tumor-associated antigen co-stimulation |
基金项目: |
|
摘要点击次数: 2256 |
全文下载次数: 1097 |
中文摘要: |
摘 要:嵌合型抗原受体T细胞(chimeric antigen receptor T cell,CAR-T cell)是通过基因修饰而表达肿瘤特异性的嵌合型抗原受体的T细胞,能重新识别特异的肿瘤相关性抗原(tumor-associated antigen,TAA),并对肿瘤细胞产生细胞毒性作用,发挥抗肿瘤效应。许多临床研究已经证明该疗法的可行性及安全性,并已取得令人振奋的疗效。 |
英文摘要: |
Abstract:Chimeric antigen receptor T cell(CAR-T cell) can express tumor-associated chimeric antigen receptor by genetic modification. Those cells can recognize tumor-associated antigens (TAAs) in the targeted cells,then exert antigen-specific cytotoxicity against tumor cells. Many clinical trails have demonstrated the feasibility and safety,as well as impressive effectiveness of CAR-T cell therapy. |
在线阅读
查看全文 查看/发表评论 下载PDF阅读器 |