| 李 芳,翟从劼,田延锋.miRNA-214在乳腺癌组织中的表达及其意义[J].中国肿瘤,2016,25(10):816-819. |
| miRNA-214在乳腺癌组织中的表达及其意义 |
| Expression of miRNA-214 in Breast Cancer and Its Significance |
| 投稿时间：2015-11-14 |
| DOI：10.11735/j.issn.1004-0242.2016.10.A014 |
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| 中文关键词: miRNA-214 乳腺癌 qPCR |
| 英文关键词:miRNA-214 breast cancer qPCR |
| 基金项目:河北省科技支撑计划项目（14277755D） |
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| 中文摘要: |
| 摘 要：［目的］ 探讨miRNA-214在乳腺癌组织中的表达及其与临床病理特征及预后的关系。［方法］ 应用实时定量qPCR检测45例乳腺癌及癌旁正常组织中miRNA-214的含量，分析其与临床病理特征、预后的关系。［结果］ 乳腺癌组织中miRNA-214的含量明显低于癌旁正常组织，差异有统计学意义（P＜0.01）；miRNA-214在Ki-67阴性组的表达量明显高于Ki-67阳性组，差异具有统计学意义（P=0.01）；miRNA-214水平与患者的年龄、月经状况、临床分期、肿瘤大小、淋巴结转移、ER、PR、Her-2及p53的表达均无关（P＞0.05）。［结论］ miRNA-214在乳腺癌组织中呈低表达，并与Ki-67表达相关，提示其可能与乳腺癌的发生、发展及预后有关。 |
| 英文摘要: |
| Abstract：［Purpose］ To explore the expression of miRNA-214 and the correlation between miRNA-214 and clinical pathologic features and prognosis in breast cancer. ［Methods］ The expression of miRNA-214 was examined by qPCR in 45 cases of breast cancer and normal tissue adjacent to carcinoma. Its relationship with clinical pathologic features and prognosis was analyzed. ［Results］ Compared with normal tissue，the expression of miRNA-214 decreased in breast cancer tissue，the difference was statistically significant(P<0.01). The expression of miRNA-214 in Ki-67 negative group was obviously higher than Ki-67 positive group，with statistically significant difference(P=0.01). The miRNA-214 level was irrelevant with the patient’s age，menstrual status，clinical stage，tumor size，lymph node metastasis，ER，PR，Her-2 and p53(P>0.05). ［Conclusion］ The miRNA-214 shows low expression in breast cancer，and relates to the expression of Ki-67，which suggests that miRNA-214 may be associated with the occurrence，development and prognosis of breast cancer. |
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