| 谢国丰,卢伟焰,曹卡加.2型糖尿病对鼻咽癌患者预后的影响[J].中国肿瘤,2017,26(1):63-67. |
| 2型糖尿病对鼻咽癌患者预后的影响 |
| Relationship of Type 2 Diabetes with Prognosis of Patients with Nasopharyngeal Cancer |
| 投稿时间：2016-04-19 |
| DOI：10.11735/j.issn.1004-0242.2017.01.A010 |
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| 中文关键词: 2型糖尿病 鼻咽癌 预后 |
| 英文关键词:type 2 diabetic mellitus nasopharyngeal cancer prognosis |
| 基金项目:广州市医药卫生科技一般引导项目（2015A011090） |
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| 中文摘要: |
| 摘 要：［目的］ 观察2型糖尿病对鼻咽癌患者预后的影响。［方法］ 对2003年12月至2011年1月180例鼻咽癌患者资料进行回顾性分析。糖尿病组为2型糖尿病合并鼻咽癌病例共90例，对照组采用病例匹配方法，共纳入90例非糖尿病的鼻咽癌患者，应用Kaplan-Meier和Log-rank法计算和比较两组患者的5年总生存率、无复发生存率和无转移生存率。［结果］ 对照组和糖尿病组的5年总生存率分别是78.9%和68.9%（P＞0.05）；5年无转移生存率分别是89.7%和83.9%（P＞0.05）；5年无复发生存率分别为89.3%和78.2%（P＜0.05）。COX风险回归模型多因素分析结果显示，性别是局部晚期鼻咽癌总生存的独立预后因素（P=0.039）。［结论］ 2型糖尿病使鼻咽癌的复发率升高，值得进一步研究。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the relationship of type 2 diabetic mellitus(DM) with prognosis of patients with nasopharyngeal cancer(NPC). ［Methods］ Clinical data of 180 patients with NPC admitted between December 2003 and January 2011 were retrospectively reviewed，including 90 patients with type 2 diabetic mellitus(DM group)，and 90 patients without type 2 diabetic mellitus(NDM group). Then，Kaplan-Meier analysis and Log-rank test were used to calculate the distant metastasis-free survival (DMFS)，locoregional relapse-free survival (LRFS) and 5-year overall survival(OS) rate in two groups. ［Results］ The 5-year OS rate of NDM group and DM group were 78.9% and 68.9%，respectively（P＞0.05），the 5-year DMFS rate were 89.7% and 83.9%，respectively（P＞0.05），and the 5-year LRFS rate were 89.3% and 78.2%，respectively（P<0.05）. Multivariate analysis showed that gender was an independent prognostic factor for OS of NPC patients（P=0.039）. ［Conclusion］ The study shows that NPC patients with type 2 diabetes have a worse locoregional relapse-free survival than those without diabetes. |
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