| 宋 艳,黄 璇,刘秀云.Pax8在330例不同系统上皮及上皮源性肿瘤组织中的表达研究[J].中国肿瘤,2017,26(4):297-301. |
| Pax8在330例不同系统上皮及上皮源性肿瘤组织中的表达研究 |
| Expression of Pax8 in Human Epithelial Cells and Carcinomas of Different Systems |
| 投稿时间：2016-10-09 |
| DOI：10.11735/j.issn.1004-0242.2017.04.A011 |
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| 中文关键词: Pax8 女性生殖系统 泌尿系统 免疫组化 组织芯片 |
| 英文关键词:Pax8 female reproductive system urinary system imunohistochemistry tissue microarray |
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| 中文摘要: |
| 摘 要：［目的］ 探讨Pax8蛋白在不同系统上皮和上皮源性肿瘤中的表达及其临床意义。［方法］ 采用免疫组化及组织芯片的方法检测Pax8蛋白在不同系统上皮与上皮源性肿瘤中的表达。采用SPSS17.0统计软件进行统计学分析。［结果］ Pax8蛋白在各个系统中的表达差异具有统计学意义(P＜0.001)。正常组织中，Pax8在内分泌系统、泌尿系统及女性生殖系统上皮中的表达较多，阳性率分别是40.0%、60.0%和76.9%。肿瘤组织中，Pax8在肾细胞癌的阳性表达率为65.2％，甲状腺癌中的表达为66.7%，子宫内膜腺癌中的表达为80.0%。在卵巢中，92.8%浆液性癌表达Pax8，卵巢子宫内膜样癌、透明细胞癌中Pax8的阳性表达率为81.8%和82.3%。Pax8在其他系统的上皮及其肿瘤中微弱表达或者不表达。［结论］ Pax8蛋白主要特异性表达在泌尿及苗勒氏起源器官的上皮及上皮源性肿瘤中，在甲状腺也可见较强表达，可用于常规病理诊断的鉴别诊断。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the expression and clinical significance of Pax8 protein in different types of human epithelial cells and carcinomas.［Methods］ The expression of Pax8 protein in epithelial cells and tumors from 330 samples of different systems was detected by immunohistochemistry on tissue microarray. Statistical analysis was performed with SPSS17.0 software.［Results］ The expression of Pax8 protein in various systems showed a certain degree of specificity(P＜0.001). In normal tissues，there were more expression in the epithelial cells from endocrine system，urinary system and female reproductive system，with a positive rate of 40.0%，60.0% and 76.9%，respectively. Among the tumors from different organs，the positive expression rate of Pax8 in renal cell carcinoma，thyroid carcinoma and endometrial adenocarcinoma was 65.2%，66.7%，and 80.0%，respectively. The positive expression rates of Pax8 were 92.8%，81.8% and 82.3% in serous carcinomas，endometrial carcinomas and clear cell carcinomas of the ovary，respectively. Pax8 was weakly expressed or not expressed in normal epithelial cells or carcinomas of other systems.［Conclusion］ Pax8 protein is mainly expressed in epitheliums and epithelial tumors of urogenital and Mullerian origin；also strongly expressed in thyroid carcinoma，indicating that Pax8 might be used in the differential diagnosis of routine pathology. |
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