| 王伟伟,张钦凤,肖丽霞.COX-2 765基因多态性与环境因素在食管鳞癌发病中的交互作用[J].中国肿瘤,2017,26(5):351-354. |
| COX-2 765基因多态性与环境因素在食管鳞癌发病中的交互作用 |
| Interaction Between COX-2 765 Polymorphism and Environmental Factors in Pathogenesis of Esophageal Squamous Cell Carcinoma |
| 投稿时间：2016-03-07 |
| DOI：10.11735/j.issn.1004-0242.2017.05.A006 |
|
 |
| 中文关键词: COX-2 环境因素 交互作用 食管癌 鳞癌 病例对照研究 |
| 英文关键词:COX-2 environmental factors interaction esophageal cancer squamous cell carcinoma case-control study |
| 基金项目:山东省高等学校科技计划项目（J14LK04）； |
|
| 摘要点击次数: 1835 |
| 全文下载次数: 837 |
| 中文摘要: |
| 摘 要：［目的］ 评价COX-2 765基因多态性与环境因素在食管癌的发生过程中是否存在交互作用。［方法］ 采用病例对照研究，病例组食管癌202例，对照组236名正常人。应用Taqman探针法检测COX-2 765位点单核苷酸多态性；运用相乘模型计算COX-2 765基因型与环境因素间的交互作用。［结果］ 病例组COX-2 765位点C等位基因频率为15.8%，对照组为3.0%，两组差异有统计学意义（?字2=44.489，P<0.001）。携带COX-2 765 GC基因型的个体患食管癌的风险比COX-2 765 GG基因型增加（HR=7.354，95%CI：3.972~13.617)。COX-2 765基因位点与反酸、住所周围有无工厂、住所周围有无空气污染、住所周围有无水污染、10年前水源和被动吸烟等因素的相乘模型交互作用有统计学意义（P<0.05）。［结论］ COX-2 765 C等位基因可能为食管癌的遗传危险因素，且COX-2 765基因型与反酸、住所周围有无工厂、住所周围有无空气污染、住所周围有无水污染、10年前水源和被动吸烟存在相乘模型交互作用。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the possible interaction between COX-2 765 polymorphism and environmental risk factors in the pathogenesis of esophageal squamous cell carcinoma. ［Methods］ According to the case-control design，202 cases with esophagal cancer and 236 controls were enrolled in this study. COX-2 765 single nucleotide polymorphism was detected with Taqman probe， and multiplicative model was used to analyze interaction between COX-2 765 genotype and environmental factors. ［Results］ Allele frequency of C of COX-2 765 15.8% in case group，was higher than that in control group（15.8% vs 3.0%，χ2=44.489，P<0.001）. The person with COX-2 765 GC genotype had a higher risk for esophageal squamous cell carcinoma than that with COX-2 765 GG genotype(HR=7.354，95%CI：3.972~13.617). Multiplicative model interaction was found that there were interactions of COX-2 765 genotype with acid reflux，factories，air and water pollution around residence，and passive smoking (P<0.05). ［Conclusion］ COX-2 765 C allele gene may be associated with esophageal cancer. Multiplicative model interaction exists between COX-2 765 genotype and acid reflux，factories，air，water pollution around residence，and passive smoking. |
|
在线阅读
查看全文 查看/发表评论 下载PDF阅读器 |