| 马 箐,马山蕊,王 孟.MicroRNAs与食管癌关系的研究进展[J].中国肿瘤,2017,26(5):371-377. |
| MicroRNAs与食管癌关系的研究进展 |
| Research Progress on Relationship Between MicroRNAs and Esophageal Cancer |
| 投稿时间：2016-06-30 |
| DOI：10.11735/j.issn.1004-0242.2017.05.A010 |
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| 中文关键词: microRNAs 食管癌 癌前病变 早期诊断 分子标志物 |
| 英文关键词:microRNAs esophageal cancer precancerous lesion early diagnosis molecular marker |
| 基金项目:国家自然科学基金（81473056） |
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| 摘要点击次数: 1955 |
| 全文下载次数: 738 |
| 中文摘要: |
| 摘 要：MicroRNAs(miRNAs)是一类长18～24个核苷酸的内源性非编码小分子RNA，可通过负调控靶基因，参与体内的基本信号传导途径。其主要来源于组织、血液、唾液，越来越多的研究资料表明不同来源的miRNAs在食管癌的发生、发展过程中发挥着肿瘤癌基因或抑癌基因的作用，并且在食管癌及其癌前病变的早期诊断、早期治疗及预后中有可能成为新型的分子标志物和基因治疗的新靶点。全文就不同来源的miRNAs在食管癌及其癌前病变的诊断、预后及基因治疗方面的潜在作用作一综述。 |
| 英文摘要: |
| Abstract：MicroRNAs(miRNAs) are families of noncoding short RNA with 18~24 nucleotides long that regulate gene expression at the post-transcriptional level. MicroRNAs are mainly from tissue，blood and saliva.More and more studies have demonstrated that miRNAs from different sources acted as oncogene and anti-oncogene in esophageal cancer(EC) and they may serve as new cancer biomarkers or molecular target in the early diagnosis，treatment and prognosis of EC. This study focuses on the relationship between miRNAs from different sources and precancerous lesion of EC，as well as their potential use in the diagnosis，prognosis and gene therapy for precancerous lesion and EC. |
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