| 车轶群,王 迪,沈 迪.肝癌患者血清中黄曲霉毒素白蛋白加合物与肝肾功能的关系[J].中国肿瘤,2017,26(6):490-493. |
| 肝癌患者血清中黄曲霉毒素白蛋白加合物与肝肾功能的关系 |
| Detection of Serum AFB1-alb Adduct and Its Association with Hepatic and Renal Functions in Patients with Hepatocellular Carcinoma |
| 投稿时间：2017-02-10 |
| DOI：10.11735/j.issn.1004-0242.2017.06.A014 |
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| 中文关键词: AFB1-alb加合物 肝肿瘤 肝肾功能 |
| 英文关键词:AFB1-alb adduct hepatocellular neoplasms hepatic and renal functions |
| 基金项目:北京市自然科学基金（7162164）；首都卫生发展科研专项（首发2014-4-4028） |
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| 中文摘要: |
| 摘 要：［目的］ 评价肝癌患者AFB1-alb加合物的暴露水平以及与肝肾功能的关系。［方法］ 采用ELISA试剂盒分析82例肝癌患者、31例肝炎患者和51名健康人血清中的AFB1-alb加合物，同时使用全自动生化仪检测不同AFB1-alb加合物水平肝癌患者的肝肾功能，核磁共振成像（MRI）验证肝损伤。［结果］ AFB1-alb加合物在肝癌患者血清中的水平高于健康人，两者之间差别有统计学意义（P<0.05）。肝癌和肝炎两组患者之间AFB1-alb加合物水平无明显差异。AFB1-alb加合物的暴露水平与身体质量指数有关，而与年龄、性别及居住地无关。血清中的AFB1-alb加合物与总胆红素、谷酰转肽酶、肌酐、尿酸、甘油三脂、胆固醇相关，而与白蛋白、转氨酶、碱磷酶、尿素无明显相关。AFB1-alb加合物高水平组MRI显示脂肪变性的比例高于低水平组(48.8% vs 25.6%)，两组之间差异有统计学意义。［结论］ 肝癌患者血清中的AFB1-alb加合物高暴露水平影响肝肾功能，AFB1-alb加合物可能成为肝癌诊断的血清学潜在标志物。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the level of AFB1-alb adduct in serum samples from hepatocellular carcinoma patients and its association with hepatic and renal functions. ［Methods］ Blood samples were collected from 82 hepatocellular carcinoma patients，31 hepatitis patients and 51 healthy controls. The level of AFB1-alb adduct was detected by ELISA.AFB1-alb adduct，albumin，total bilirubin，AST，ALT，ALP，GGT，creatinine，TG，CHOL and Urea were detected by automatic biochemical analyzer，and hepatic lesion was evaluated by magnetic resonance imaging (MRI). ［Results］ Hepatocellular carcinoma patients had higher AFB1-alb adduct levels than healthy control，with significant difference(P<0.05). There was no remarkable difference between hepatocellular carcinoma and hepatitis patients. AFB1-alb adduct levels did not show significant correlations with age，gender and residence. Additionally，there was significant relationship between body mass index and AFB1-alb adduct. Patients with AFB1-alb adduct levels greater than average had significantly elevated level of total bilirubin，GGT，creatinine，Uric，TG and CHOL. Nevertheless，the level of albumin，ALT，AST，ALP and Urea showed no correlation with the level of AFB1-alb adduct. High AFB1-alb adduct level group by MRI showed that the proportion of hepatic lesion was higher than that of the low group(48.8% vs 25.6%)，with significant difference(P<0.05).［Conclusions］ High exposure levels of serum AFB1-alb adduct could affect the functions of liver and kidney in hepatocellular carcinoma patients. It implies that AFB1-alb adduct might be a potential biomarker in the diagnosis of hepatocellular carcinoma. |
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