| 邱小玲,徐 燕,王孟昭.以多发磨玻璃影为表现肺癌的评价和处理[J].中国肿瘤,2017,26(7):540-543. |
| 以多发磨玻璃影为表现肺癌的评价和处理 |
| Diagnostic Evaluation and Treatment of Multiple Neoplastic Pulmonary Nodules with Ground-glass Opacity |
| 投稿时间：2016-08-29 |
| DOI：10.11735/j.issn.1004-0242.2017.07.A008 |
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| 中文关键词: 肺肿瘤 磨玻璃结节 多原发癌 诊断 治疗 |
| 英文关键词:lung neoplasms ground-glass opacity nodules multiple primary cancer diagnosis treatment |
| 基金项目: |
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| 中文摘要: |
| 摘 要：近年来，肺部磨玻璃影(ground-glass opacity，GGO）逐渐得到临床医生关注，GGO多数情况下呈惰性，但也可进一步发展为肺癌。肺多发GGO肺癌大部分为多原发癌（multiple primary lung cancer，MPLC），不是肺内转移癌。对于怀疑为多发GGO肺癌，治疗方式主要为手术切除，同时获得病理诊断，通过不同病灶的驱动基因检测最终明确多原发癌的诊断。手术方式可以选择亚肺叶切除或楔形切除最主要的病灶。研究表明最主要病灶的直径和病灶类型与预后明显相关，而遗留的GGO病灶是否长大、是否出现新的GGO病灶、是否所有的GGO病灶被处理对患者的预后影响小。该文旨在正确评价和处理肺多发GGO肺癌。 |
| 英文摘要: |
| Abstract：Pulmonary ground-glass opacity(GGO) has raised increasing attention of clinicians in recent years. In most cases，GGOs are indolent，while in other cases，they may grow malignant. Most of lung cancers with multiple GGOs arise as multiple primary lung cancer(MPLC) rather than intrapulmonary spread. For suspected lung cancer with multiple GGOs，the major treatment is surgical resection；then the histological diagnosis can be obtained and MPLC can be identified through driver gene detection of different lesions. Sublobar or wedge resection of the primary lesions can be considered. Recent research demonstrated that the size and type of the main lesions were associated with prognosis，whereas growth of the residual GGOs，the development of new GGOs，or whether all GGOs were treated or not might be less important. In this review，the evaluation and management of lung cancer with multiple GGOS are focused on. |
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