| 闫 宇,任 予,范金虎.65岁以上中国老年女性原发性乳腺癌临床病理特征及治疗分析：多中心10年回顾性研究[J].中国肿瘤,2017,26(7):561-566. |
| 65岁以上中国老年女性原发性乳腺癌临床病理特征及治疗分析：多中心10年回顾性研究 |
| Clinicopathologic Characteristics and Treatment Patterns of Primary Breast Cancer in Elderly Women：A Retrospective Multicenter Study |
| 投稿时间：2016-11-02 |
| DOI：10.11735/j.issn.1004-0242.2017.07.A012 |
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| 中文关键词: 乳腺癌 老年人 女性 临床病理学 治疗 回顾性研究 |
| 英文关键词:breast cancer elderly female clinicopathology treatment retrospective study |
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| 摘要点击次数: 2099 |
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| 中文摘要: |
| 摘 要：［目的］ 研究65岁以上老年女性原发性乳腺癌的风险暴露因素、临床病理特征以及治疗特征，为老年女性乳腺癌的诊治提供依据。［方法］ 回顾性分析全国7个不同地区具有代表性的7家医院收集的4211例乳腺癌患者信息，将65岁以上患者作为研究对象（老年组），50～64岁年龄组作为对照组。统计学方法为卡方检验和Fisher精确检验，P<0.05具有统计学意义。［结果］ 65岁以上老年乳腺癌患者占同期乳腺癌患者的8.33%（351/4211）。平均诊断年龄和平均绝经年龄分别为70.2岁（65～86岁）和49.59岁（32～58岁）。与对照组相比，老年组具有以下特征：以体力工作、生育大于一胎、低学历、结婚早和初次生育年龄早者显著；临床病理特征方面，老年患者区域淋巴结转移少、分期早（即更多的0+Ⅰ+Ⅱ期患者）、激素受体阳性率高、Her-2低表达、Her-2亚型和三阴性亚型少。在侵袭性治疗方面，老年患者较少接受改良根治术、保乳术、放疗、化疗，更多的是接受乳腺单纯切除术。两组间内分泌治疗无显著差异。［结论］ 老年乳腺癌患者有较好的临床病理特征和生物学行为；接受侵袭性治疗少；内分泌治疗需要加强。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the clinicopathological characteristics and therapeutic patterns of breast cancer in elderly women. ［Methods］ The medical records of 4211 female patients with breast cancer were collected from 7 representative regions of China from 1999 to 2008. Data of risk factors，clinicopathological characteristics and treatment patterns were extracted and analyzed. ［Results］ Of 4211 patients，351(8.33%) patients were ≥65 years of age(elderly group). In elderly group the mean age at the diagnosis was 70.2 years(65～86 years) and the mean age of menopause was 49.6 years(32～58 years). Compared to patients aged 50~64 years(control group)，a larger proportion of patients in elderly group engaging in manual labors(P=0.034)，having multiple birth(P<0.001)，younger primiparous age(P=0.001) and less school education(P=0.018). Compare to control group，the elderly patients had axillary lymph node metastasis less frequently(P=0.001)，more early-stages(stage 0，Ⅰand Ⅱ) disease(P=0.030)，less Her-2 overexpression(P=0.005)，more ER/PR positivity(P=0.012)；for molecular subtypes，elderly patients had less Her-2 phenotype(P<0.001) and less basal-like phenotype(P<0.001). Compared to control group，lower proportion of elderly patients received modified radical mastectomy(P<0.001)，breast-conserving surgery(P<0.001)，chemotherapy(P<0.001) and radiotherapy(P<0.001)，while the elderly patients had simple mastectomy more frequently(P<0.001)，and less endocrine therapy. ［Conclusion］ Elderly breast cancer patients have a more favorable clinicopathologic profile and receive less aggressive therapy as compared to the younger counterparts. However，endocrine therapy needs to be strengthened. |
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