| 潘 磊,顾冬英,胡凯敏.哺乳动物雷帕霉素靶蛋白基因多态性（rs2295080）与结直肠癌患者预后的关联性研究[J].中国肿瘤,2017,26(7):567-573. |
| 哺乳动物雷帕霉素靶蛋白基因多态性（rs2295080）与结直肠癌患者预后的关联性研究 |
| Polymorphism in mTOR(rs2295080) and Its Association with Survival of Colorectal Cancer Patients |
| 投稿时间：2016-02-03 |
| DOI：10.11735/j.issn.1004-0242.2017.07.A013 |
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| 中文关键词: 结直肠癌 单核苷酸多态性 预后 mTOR |
| 英文关键词:colorectal cancer single nucleotide polymorphism prognosis mTOR |
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| 中文摘要: |
| 摘 要：［目的］ 对哺乳动物雷帕霉素靶蛋白（mTOR）基因多态性（rs2295080）与结直肠癌患者预后的相关性进行分析。［方法］ 随访行结直肠癌根治术的488例患者，提取患者静脉血标本的DNA并进行基因分型，分析mTOR rs2295080多态性与结直肠癌患者生存预后的关联。［结果］ 在结肠癌患者中，rs22995080 GG基因型携带者的预后生存较TG/TT基因型明显下降（HR=3.07，95%CI：1.15~8.22）。同时发现该作用在中分化（HR=3.74，P=0.008)，无淋巴结转移(HR=11.87，P＜0.001)和Ⅱ期(HR=14.74，P＜0.001)的结肠癌患者中更加明显。而在直肠癌患者中，rs2295080 TG/GG基因型较TT基因型可明显提升患者的预后生存（HR=0.48，95%CI：0.23~0.99）。该保护作用在无远处转移(HR=0.28，P=0.011)和Ⅲ期(HR=0.21，P=0.019)的直肠癌患者中更加明显。［结论］ mTOR rs2295080可能与结直肠癌患者的生存相关并可作为结直肠癌预测预后的生物标志物。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the association of polymorphisms in mTOR(rs2295080) and prognosis of colorectal cancer patients.［Methods］ 488 surgically resected colorectal cancer patients were divided into several groups according to their genotypes，in order to explore the links between SNP rs2295080 and the survival of colorectal cancer patients in a Chinese population. ［Results］ Patients carrying rs2295080 GG genotype survived less than those with the TG/TT genotypes (HR=3.07，95%CI：1.15~8.22) in the colon cancer subgroup. This risk effect was more remarkable among patients with moderately differentiated cancers，no lymph node metastasis，and TNM stage Ⅱ. For rectal cancer patients，rs2295080 TG/GG genotypes had better prognosis compared with the TT genotype(HR=0.48，95%CI：0.23~0.99). This risk effect was more remarkable among patients with no distant metastasis and TNM stage Ⅲ. ［Conclusions］ SNP rs2295080 may be related to the survival of colorectal cancer patients and can be a potential prognostic biomarker of colorectal cancer. |
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