| 张 婷.基于专利分析和社会网络分析的天然抗肿瘤药研究[J].中国肿瘤,2017,26(8):642-649. |
| 基于专利分析和社会网络分析的天然抗肿瘤药研究 |
| The Development Trends of Natural Antitumor Agents Based on Patent Analysis and Social Network Analysis |
| 投稿时间：2016-08-25 |
| DOI：10.11735/j.issn.1004-0242.2017.08.A011 |
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| 中文关键词: 天然抗肿瘤药 专利计量分析 社会网络分析 中心性 结构洞 |
| 英文关键词:natural antitumor agents patentometrics social network analysis degree centrality structural holes |
| 基金项目:中国医学科学院/北京协和医学院药物研究所天然药物活性物质与功能国家重点实验室开放课题（GTZK201508）；北京协和医学院协和青年基金和中央高校基本科研业务费专项（3332013151） |
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| 摘要点击次数: 1935 |
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| 中文摘要: |
| 摘 要：［目的］ 基于专利文献分析天然抗肿瘤药的发展态势。［方法］ 采用专利计量分析、社会网络分析等方法从专利申请数量、专利生命周期、专利技术领域、网络密度、中心性等方面对天然抗肿瘤药的发展态势进行深入分析。［结果］ 全球天然抗肿瘤药领域共有专利申请57 728件，近几年处于稳定的发展时期；美国和中国专利数量处于绝对领先地位，专利申请量分别为21 227件和18 172件；专利申请最多的机构是中国上海BODE基因发展有限公司和瑞士罗氏制药公司，专利数量分别为1172件和862件；专利技术领域主要集中在抗肿瘤活性和剂型的相关研究；研究主题主要涉及肿瘤相关的基因克隆表达及其编码蛋白的特征与功能研究、细胞生长因子及其受体对肿瘤细胞的影响及机制研究等14个领域。［结论］ 天然抗肿瘤药是肿瘤领域非常重要的研究方向。通过对天然抗肿瘤药的专利进行深入分析，可以了解该领域的研究现状和发展态势，为肿瘤研究和新药研发提供一定的借鉴和参考。 |
| 英文摘要: |
| Abstract：［Purpose］ To discuss the situation and development trends of natural antitumor agents by patent analysis. ［Methods］ This paper retrieved patents of natural antitumor agents in the Thomson Innovation database，and discussed the development trends from the quantities of patent applications，life circle，country/region distributions，technical fields，network density，degree centrality and other aspects by the method of patentometrics and social network analysis.［Result］ There were 57 728 patent applications，being in a steady increasing period；patent applications were concentrated in the United States and China；Shanghai Bode Gene Development Co Ltd and Roche were the two patent assignees with the most patent applications，21 227 and 18 172 respectively；technical fields were mainly concentrated in antitumor activity and preparation；research topics focused on fourteen aspects，such as tumor-related gene cloning and expression and the features and functions of their encoding protein，mechanism and effects of cell growth factor and their inhibitors on cancer cell. ［Conclusion］ Through the patent analysis of natural antitumor agents，this paper could reveal the current situation and development trends，and also provide a reference for tumor research and drug discovery. |
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