| 迟佳琦,李泉旺,胡凯文.免疫微环境与非小细胞肺癌预后关系的研究进展[J].中国肿瘤,2017,26(9):714-720. |
| 免疫微环境与非小细胞肺癌预后关系的研究进展 |
| Research Progress on the Relationship Between Immunologic Microenvironment and Prognosis of Non-small Cell Lung Cancer |
| 投稿时间：2016-09-27 |
| DOI：10.11735/j.issn.1004-0242.2017.09.A011 |
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| 中文关键词: 非小细胞肺癌 免疫微环境 预后 |
| 英文关键词:non-small cell lung cancer immunologic microenvironment prognosis |
| 基金项目:中国博士后科学基金(2016M591127)；北京中医药大学基本科研业务费自主选题项目(2016-JYB-XS168) |
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| 中文摘要: |
| 摘 要：肺癌是发病率和死亡率增长最快的恶性肿瘤，其中非小细胞肺癌（NSCLC）约占85%。肺癌的治疗已从最初的手术切除、外科辅助治疗、放化疗、靶向治疗，发展到目前比较热门的免疫治疗，但仍只有少数患者能够从中受益。大量研究发现肿瘤微环境不仅影响肿瘤的发生发展，而且与肿瘤的复发及临床结果密切相关。现主要围绕免疫细胞、免疫结构，探讨免疫微环境作为NSCLC预后标志物的研究进展。 |
| 英文摘要: |
| Abstract：Lung cancer now is the most deadly malignant disease，85% of which are non-small cell lung cancer(NSCLC). The treatment of lung cancer have advanced from the surgical resection，surgical adjuvant therapy，radiation and chemotherapy，targeted therapy，to antitumor immunotherapy，however，not all patients can benefit from these treatment. Increasing studies have indicated that tumor microenvironment not only can influence development of tumor，but also is closely related to tumor recurrence and treatment outcome. This review will focus on immune cells and immune contexture，discuss the research progress on immunologic microenvironment as a prognostic marker for NSCLC. |
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