| 黄 华,姚 婵,张 青.TRIP6在120例胃癌组织中的表达及其临床意义[J].中国肿瘤,2017,26(12):1004-1008. |
| TRIP6在120例胃癌组织中的表达及其临床意义 |
| Expression of TRIP6 in Gastric Cancer and Its Clinical Significance |
| 投稿时间：2017-09-07 |
| DOI：10.11735/j.issn.1004-0242.2017.12.A015 |
|
 |
| 中文关键词: 胃肿瘤 TRIP6 免疫组化 预后 |
| 英文关键词:gastric neoplasms TRIP6 immunohistochemistry prognosis |
| 基金项目: |
|
| 摘要点击次数: 1576 |
| 全文下载次数: 411 |
| 中文摘要: |
| 摘 要：［目的］探讨甲状腺激素受体相互作用蛋白 6（TRIP6）蛋白在胃癌中的表达及临床意义。［方法］ 采用免疫组化法检测120例胃癌组织和相应癌旁组织中TRIP6蛋白的表达，并分析其与临床病理学参数和预后的关系。［结果］ TRIP6蛋白在胃癌组织中阳性表达率为70.8%（85/120），显著高于癌旁组织的35.0%（42/120）（P<0.05）。TRIP6蛋白表达与胃癌患者的肿瘤大小、肿瘤浸润深度、分化程度、淋巴结转移、远处转移及TNM分期密切相关（P<0.05）。Kaplan-Meier分析显示TRIP6表达阳性患者有着更差的预后(5年生存率11.8% vs 45.7%，P<0.05）。多因素分析显示，胃癌患者TNM分期、远处转移以及TRIP6表达是影响胃癌患者预后的独立危险因素。 ［结论］ TRIP6蛋白在胃癌组织中表达上调，且与胃癌患者不良预后相关，TRIP6的检测将有助于胃癌的诊断、胃癌患者恶性程度和预后的评估。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the expression of thyroid receptor interacting protein 6（TRIP6）in gastric cancer and its clinical significance.［Methods］ Immunohistochemical analysis was performed to detect TRIP6 expression in 120 specimens of gastric carcinoma and adjacent cancer tissues. The relations of TRIP6 expression with clinicopathological parameters of gastric cancer and the prognosis of patients were evaluated.［Results］ Positive expression rate of TRIP6 in gastric cancer was 70.8%（85/120），which was significantly higher than that in adjacent cancer tissues(35.0%，42/120）(P<0.05). The expression of TRIP6 was correlated with the tumor size，depth of invasion，differentiation grade，lymph node metastasis，distant metastasis and TNM stages(P<0.05). Kaplan-Meier analysis showed that 5-year survival rate in TRIP6 positive patients was significantly poorer than that in TRIP6 negative patients(11.8% vs. 45.7%，P<0.05). Multivariate analysis showed that TNM stages，distant metastasis and TRIP6 expression were independent risk factors for prognosis of gastric cancer. ［Conclusion］ TRIP6 protein is up-regulated in gastric cancer tissues and is associated with a poor prognosis of patients. Detection of TRIP6 may be valuable for diagnosis and prognosis of patients with gastric cancer. |
|
在线阅读
查看全文 查看/发表评论 下载PDF阅读器 |
|
|
|