| 陈 琼,于 亮,刘曙正.林州市上消化道癌内窥镜筛查效果评价研究[J].中国肿瘤,2018,27(3):192-197. |
| 林州市上消化道癌内窥镜筛查效果评价研究 |
| Evaluation of Screening for Upper Digestive Tract Cancer in Linzhou |
| 投稿时间：2017-02-11 |
| DOI：10.11735/j.issn.1004-0242.2018.03.A006 |
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| 中文关键词: 上消化道癌 死亡率 死亡风险 筛查 肿瘤登记 病例对照研究 河南 |
| 英文关键词:upper digestive tract cancer mortality risk of death screening cancer registration case-control study Henan |
| 基金项目:中央财政转移支付项目 （2006BAl02A15） |
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| 摘要点击次数: 2043 |
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| 中文摘要: |
| 摘 要：［目的］ 利用肿瘤登记数据和上消化道癌症（食管癌和胃癌）筛查记录对人群筛查效果进行评价。［方法］ 选择林州市肿瘤登记处数据库中食管癌和胃癌死亡记录者为病例，随机选择5个与病例相同村庄、相同性别、年龄相差±2岁的存活村民作为对照，通过查询筛查档案获取病例和对照的筛查暴露信息。采用病例对照的研究方法，以内镜筛查为暴露因素，利用条件Logistic回归模型估计死亡风险比（OR）以及相应的95%可信区间（95%CI）。［结果］ 共有566例病例和2828例对照纳入统计分析。与从来没有参加筛查的人相比，筛查暴露者上消化道癌的死亡风险为0.65（95%CI：0.52～0.81）。筛查后时间<2年、2～3年和4年及以上者上消化道癌的死亡风险分别为0.86（0.42～1.75）、0.60（0.40～0.89）、0.64（0.48～0.86）；筛查年龄<50岁、50～59岁和60岁及以上者上消化道癌的死亡风险分别为0.64（0.32～1.70）、0.54（0.38～0.75）、0.76（0.56～1.04）。［结论］ 参加内窥镜筛查能够降低35%上消化道癌症的死亡风险，随着筛查后的时间增加以及筛查时年龄在50～59岁组能够增加死亡风险的降低幅度。 |
| 英文摘要: |
| Abstract：［Purpose］To evaluate the effect of endoscopic screening for upper digestive tract cancer in Linzhou. ［Methods］ A case-control study was conducted to evaluate the effectiveness of screening for upper digestive tract cancer. Five hundred and sixty-six cases who died of gastric and esophageal cancer were collected from Linzhou Cancer Registry database and 2828 local residents matched by gender and age (±2 years) were selected as controls. Taking endoscopic screening as the exposure factor，the odds ratios (OR) and 95% confidence intervals (95% CI) were estimated by conditional logistic regression. ［Results］ Compared with subjects without screening，the overall OR of upper digestive tract cancer death for individuals with screening was 0.65 (95%CI: 0.52～0.81). The ORs for lag time of 2～3 years and >4 years were 0.60 (0.40～0.89) and 0.64 (0.48～0.86)，respectively. The OR for those aged 50～59 years was 0.54 (0.38～0.75). ［Conclusion］ The results suggest a 35% reduction in risk of upper digestive tract cancer mortality by endoscopic screening. |
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