| 袁世洋,谢军平.影响TKI疗效个体化差异的基因相关因素研究进展[J].中国肿瘤,2018,27(5):369-375. |
| 影响TKI疗效个体化差异的基因相关因素研究进展 |
| Genetic Factors Influencing Efficacy of EGFR-TKI Therapy in Different Individuals |
| 投稿时间：2018-01-26 |
| DOI：10.11735/j.issn.1004-0242.2018.05.A010 |
|
 |
| 中文关键词: 表皮生长因子受体—酪氨酸激酶抑制剂 基因突变 非小细胞肺癌 影响因素 |
| 英文关键词:epidermal growth factor receptor- tyrosine kinase inhibitor(EGFR-TKI) gene mutation non-small cell lung cancer(NSCLC) influencing factor tumor heterogeneity |
| 基金项目:江西省科技厅对外科技合作项目（20144BDH80013）； |
|
| 摘要点击次数: 1545 |
| 全文下载次数: 388 |
| 中文摘要: |
| 摘 要：表皮生长因子受体—酪氨酸激酶抑制剂（epidermal growth factor receptor-tyrosine kinase inhibitor，EGFR-TKI）对晚期非小细胞肺癌（non-small cell lung cancer，NSCLC）患者疗效显著，但仍存在较大的个体差异，且治疗后必然出现的耐药现象限制了该疗法进一步的临床应用。因此，科学地预测和评估TKI治疗敏感性并尽早地预防和缓解该疗法可能导致的耐药性成为临床亟待解决的问题。该文从基因层面对近年关于TKI疗效个体化差异的影响因素作一综述。 |
| 英文摘要: |
| Abstract：Epidermal growth factor receptor-tyrosine kinase inhibitors(EGFR-TKI) therapy is effective for some patients with advanced non-small cell lung cancer(NSCLC). However，there are significant individualized differences and the drug resistance frequently occurs after treatment，which restrains its further clinical application. Therefore，it is crucial to evaluate and predict the individualized sensitivity，and to prevent or alleviate the drug resistance in TKI therapy. In this article，the recent progress on genetic factors related to TKI efficacy in different individuals are reviewed. |
|
在线阅读
查看全文 查看/发表评论 下载PDF阅读器 |