| 顾秀瑛,郑荣寿,曾红梅.2008~2012年全国肿瘤登记地区胆道恶性肿瘤发病和死亡分析[J].中国肿瘤,2018,27(7):481-488. |
| 2008~2012年全国肿瘤登记地区胆道恶性肿瘤发病和死亡分析 |
| Incidence and Mortality of Biliary Tract Cancer in Cancer Registration Areas in China，2008~2012 |
| 投稿时间：2018-04-09 |
| DOI：10.11735/j.issn.1004-0242.2018.07.A001 |
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| 中文关键词: 胆道肿瘤 发病率 死亡率 肿瘤登记 中国 |
| 英文关键词:biliary tract cancer incidence mortality cancer registry China |
| 基金项目:中国医学科学院医学与健康科技创新工程经费资助（2016-12M-2-004）；科技部基础工作专项（2014FY121100） |
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| 中文摘要: |
| 摘 要：［目的］ 分析 2008~2012年全国肿瘤登记地区胆道恶性肿瘤的发病与死亡情况及变化趋势。［方法］ 利用2008~2012年全国135个肿瘤登记处的胆道恶性肿瘤资料，分析不同地区、性别和年龄胆道恶性肿瘤的发病率和死亡率水平及其变化趋势。［结果］ 2008～2012年全国肿瘤登记地区胆道恶性肿瘤发病率为4.12/10万（男性3.72/10万，女性4.52/10万），中标发病率为2.56/10万，世标发病率为2.54/10万。城市肿瘤登记地区胆道恶性肿瘤发病率为4.94/10万，农村地区为2.83/10万。东、中、西部肿瘤登记地区发病率分别为4.57/10万、2.99/10万和3.16/10万。同期全国肿瘤登记地区胆道恶性肿瘤死亡率为3.25/10万（男性2.94/10万，女性3.56/10万），中标死亡率为1.97/10万，世标死亡率为1.95/10万。城市肿瘤登记地区胆道恶性肿瘤死亡率为3.97/10万，农村地区为2.13/10万。东、中、西部肿瘤登记地区死亡率分别为3.68/10万、2.19/10万和2.28/10万。胆道恶性肿瘤的年龄别发病率和死亡率均随年龄增长而升高。2008~2012年胆道肿瘤总体［年度平均变化百分比（AAPC）=-2.5%，95%CI：-4.5%~-0.5%］、女性（AAPC=-3.5%，95%CI：-5.6%~-1.4%）和城市地区（AAPC=-3.7%，95%CI：-6.0%~-1.4%）的发病率呈明显下降趋势（P<0.05），农村地区的死亡率呈明显上升趋势（AAPC=4.8%，95%CI：1.5%~8.2%，P<0.05）。 ［结论］ 2008~2012年全国肿瘤登记地区胆道恶性肿瘤总体发病率呈下降趋势，但农村地区死亡率明显增长，应根据胆道恶性肿瘤实际的流行分布特点制定相应防控策略。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the incidence and mortality of biliary tract cancer in cancer registration areas in China from 2008 to 2012. ［Methods］ The registration data during 2008 to 2012 from 135 cancer registries were used to estimate biliary tract cancer incidence and mortality and their changing trends in cancer registration areas in China by location，gender and age groups. ［Results］ The crude incidence rate of biliary tract cancer was 4.12/105(3.72/105 in males and 4.52/105 in females) and the age-standardized rate by Chinese standard population was 2.56/105 and that by world standard population was 2.54/105 in cancer registration areas in China from 2008 to 2012. The crude incidence rate of biliary tract cancer was 4.94/105 in urban cancer registration areas and 2.83/105 in rural cancer registration areas. The crude incidence rates in eastern，middle and western cancer registration areas were 4.57/105，2.99/105 and 3.16/105，respectively. The crude mortality rate of biliary tract cancer was 3.25/105(2.94/105 in males and 3.56/105 in females) and the age-standardized mortality rate by Chinese standard population was 1.97/105 and the age-standardized mortality rate by Segi’s population was 1.95/105 in cancer registration areas in China from 2008 to 2012. The crude mortality rate of biliary tract cancer was 3.97/105 in urban cancer registration areas and 2.13/105 in rural cancer registration areas. The crude mortality rates in eastern，middle and western cancer registration areas were 3.68/105，2.19/105 and 2.28/105，respectively. The age specific incidence and mortality rates were dramatically increased with age increase. The incidence rates of both gender(AAPC=-2.5%，95%CI：-4.5%~-0.5%)，females (AAPC=-3.5%，95%CI：-5.6%~-1.4%)and city residents(AAPC=-3.7%，95%CI：-6.0%~-1.4%) declined significantly during 2008 to 2012 in cancer registration areas in China (P<0.05). However，the trends of mortality in rural areas were increasing rapidly(AAPC=4.8%，95%CI：1.5%~8.2%，P<0.05). ［Conclusion］ The incidence rate of biliary tract cancer shows a significant decline in cancer registration areas in China between 2008 and 2012，and the growth trend at rural area is obvious. Corresponding prevention and control strategies should be developed according to the actual prevalence of biliary tract cancer. |
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